Mohammad Javad Rasaee | Assay development | Excellence in Innovation

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Prof. Mohammad Javad Rasaee | Assay development | Excellence in Innovation

Faculty memebr at Tarbiat Modares Uninersity, Iran📖

Dr. Mohammad Javad Rasaee is a distinguished professor in the Department of Medical Biotechnology and Biochemistry at Tarbiat Modares University, Tehran, Iran. With over three decades of academic, research, and administrative experience, he has significantly contributed to the fields of medical biotechnology and clinical biochemistry. Dr. Rasaee’s pioneering work has earned him numerous national and international accolades, including the Razi Research Festival Prize and several awards for groundbreaking research in drug abuse detection, cancer therapies, and nanotechnology. He has also served as an advisor and director in key national scientific bodies and continues to mentor the next generation of researchers.

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Education Background🎓

Dr. Rasaee holds a Ph.D. in Biochemistry with a specialization in Bioorganic Chemistry from Delhi University, India (1990), an M.Sc. in Chemistry (Honors) from Jamia Millia Islamia, Delhi, India (1987), and a B.Sc. in Chemistry from the same institution (1984). His foundational education was completed at Jelveh High School, Tehran, where he excelled in Natural Sciences (1978).

Professional Experience🌱

Dr. Rasaee began his academic career as an Assistant Professor at Tarbiat Modares University in 1990 and has since risen to the rank of Professor in the Department of Medical Biotechnology. He has held leadership roles, including Dean of the Faculty of Medical Sciences, Director of the Biotechnology Research and Development Center, and Advisor to the Minister of Science, Research, and Technology. His research efforts have led to the development of innovative diagnostic kits, nanotechnology-based cancer treatments, and a subunit vaccine for COVID-19. Dr. Rasaee has also directed numerous national and institutional committees, significantly shaping Iran’s biotechnological and scientific landscape.

Research Interests🔬

Dr. Rasaee’s research focuses on the development of diagnostic tools, cancer therapeutics, and nanobiotechnology. He has led innovative projects in immunochemical assay development, rapid detection kits for biomarkers, nanogold-based photothermal cancer treatment, and subunit vaccines for infectious diseases. His recent work includes the development of recombinant ACEII for therapeutic applications and biomarker identification for early cancer detection.

Author Metrics

Dr. Rasaee has published extensively in reputable journals, with a significant focus on immunochemistry, biotechnology, and nanotechnology applications in medicine. His research output includes several high-impact articles, and he serves on the editorial boards of prominent scientific journals such as the Iranian Journal of Biotechnology and Iranian Journal of Asthma, Allergy, and Immunology. His contributions to science are widely recognized, reflected in his citation metrics and continued collaborations in cutting-edge research.

Publications Top Notes 📄

1. Modified Salting-Out Method: High-Yield, High-Quality Genomic DNA Extraction from Whole Blood Using Laundry Detergent

  • Authors: H. Nasiri, M. Forouzandeh, M.J. Rasaee, F. Rahbarizadeh
  • Journal: Journal of Clinical Laboratory Analysis
  • Year: 2005
  • Volume: 19
  • Issue: 6
  • Pages: 229-232
  • DOI: 10.1002/jcla.20063
  • Abstract: This paper presents a modified salting-out method for genomic DNA extraction from whole blood using laundry detergent. The method significantly improves DNA yield and quality, making it highly suitable for clinical and research applications in genetics.
  • Citations: 237

2. Overexpression of Anti-MUC1 Single-Domain Antibody Fragments in the Yeast Pichia pastoris

  • Authors: F. Rahbarizadeh, M.J. Rasaee, M. Forouzandeh, A.A. Allameh
  • Journal: Molecular Immunology
  • Year: 2006
  • Volume: 43
  • Issue: 5
  • Pages: 426-435
  • DOI: 10.1016/j.molimm.2005.06.008
  • Abstract: This study investigates the overexpression of anti-MUC1 single-domain antibody fragments in Pichia pastoris. The work explores the potential of yeast-based systems for producing therapeutic antibody fragments, which are pivotal for cancer immunotherapy targeting MUC1.
  • Citations: 121

3. Radiosensitization Effect of Folate-Conjugated Gold Nanoparticles on HeLa Cancer Cells Under Orthovoltage Superficial Radiotherapy Techniques

  • Authors: K. Khoshgard, B. Hashemi, A. Arbabi, M.J. Rasaee, M. Soleimani
  • Journal: Physics in Medicine & Biology
  • Year: 2014
  • Volume: 59
  • Issue: 9
  • Page: 2249
  • DOI: 10.1088/0031-9155/59/9/2249
  • Abstract: This research explores the radiosensitization effect of folate-conjugated gold nanoparticles on HeLa cancer cells under orthovoltage superficial radiotherapy. The study demonstrates the ability of these nanoparticles to enhance the efficacy of radiation therapy, offering new strategies in cancer treatment.
  • Citations: 118

4. Production and Characterization of Anti-(Mucin MUC1) Single-Domain Antibody in Tobacco (Nicotiana tabacum Cultivar Xanthi)

  • Authors: A. Ismaili, M. Jalali-Javaran, M.J. Rasaee, F. Rahbarizadeh
  • Journal: Biotechnology and Applied Biochemistry
  • Year: 2007
  • Volume: 47
  • Issue: 1
  • Pages: 11-19
  • DOI: 10.1042/BA20060109
  • Abstract: The paper reports on the production of anti-MUC1 single-domain antibodies in tobacco plants (Nicotiana tabacum). This approach provides a novel, cost-effective method for producing therapeutic antibodies using plant expression systems.
  • Citations: 84

5. Selection of DNA Aptamers Against Human Cardiac Troponin I for Colorimetric Sensor-Based Dot Blot Application

  • Authors: G.S. Dorraj, M.J. Rasaee, A.M. Latifi, B. Pishgoo, M. Tavallaei
  • Journal: Journal of Biotechnology
  • Year: 2015
  • Volume: 208
  • Pages: 80-86
  • DOI: 10.1016/j.jbiotec.2015.02.014
  • Abstract: This paper discusses the selection of DNA aptamers against Human Cardiac Troponin I for the development of a colorimetric sensor-based dot blot assay. The findings highlight the potential of aptamers in early diagnosis of heart-related conditions.
  • Citations: 80

Conclusion

Dr. Mohammad Javad Rasaee’s career demonstrates a profound commitment to excellence and innovation in medical biotechnology. His pioneering contributions to diagnostics, cancer therapy, and nanobiotechnology position him as an exemplary candidate for the Research for Excellence in Innovation award. While there are opportunities to further enhance his work through broader international collaborations and commercialization efforts, his already significant impact in these fields marks him as a leader whose continued innovations will shape the future of medical science. Recognizing him for this award would further encourage his contributions to the advancement of global healthcare.