Assistant Professor at Shiraz University of Medical Sciences, Iran📖
Dr. Fatemeh Safari is an Assistant Professor at the Diagnostic Laboratory Science and Technology Research Center, Shiraz University of Medical Sciences, Iran. She holds a PhD in Medical Biotechnology from Tabriz University of Medical Sciences, where she also completed her MSc in the same field. Her academic journey began with a BSc in Nursing from Shiraz University of Medical Sciences. With expertise in genome editing, cell culture, and protein biochemistry, Dr. Safari has contributed significantly to the field of biotechnology, specializing in gene expression regulation and improving recombinant CHO cell productivity.
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Education Background🎓
- PhD in Medical Biotechnology
Tabriz University of Medical Sciences, Tabriz, Iran (2015-2021)
- MSc in Medical Biotechnology
Tabriz University of Medical Sciences, Tabriz, Iran (2010-2013)
Top student in the program, elected student by the organization for Gifted and Talented Education
- BSc in Nursing
Shiraz University of Medical Sciences, Shiraz, Iran (2001-2004)
Elected student by the organization for Gifted and Talented Education
Professional Experience🌱
- Assistant Professor, Diagnostic Laboratory Science and Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran (2024–Present)
In charge of the cell culture room, designing and implementing research projects, and mentoring MSc and Ph.D. students.
- Senior Researcher, Diagnostic Laboratory Science and Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran (2020–2023)
Led research in genome editing, cell culture, and protein biochemistry techniques.
- Laboratory Assistant, R&D Applied Drug Research Center, Tabriz University of Medical Sciences, Tabriz, Iran (2013–2014)
Gained hands-on experience in animal studies, cell culture, and immunization techniques.
- Emergency Medical Technician, EMS and Disaster Management Center, Shiraz, Fars, Iran (2005–2013)
Trained in resuscitation and participated in disaster and emergency medical events.
Dr. Safari’s research primarily focuses on genome editing using the CRISPR/Cas9 system, regulation of gene expression, and the enhancement of CHO cell productivity. She is also dedicated to advancing protein expression and purification techniques, particularly in the fields of molecular cloning and cell-based assays. Furthermore, Dr. Safari investigates small animal models and stem cell culture for therapeutic applications.
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Publications Top Notes 📄
1. CRISPR Cpf1 Proteins: Structure, Function, and Implications for Genome Editing
- Authors: F. Safari, K. Zare, M. Negahdaripour, M. Barekati-Mowahed, Y. Ghasemi
- Journal: Cell & Bioscience
- Volume: 9
- Pages: 1-21
- Year: 2019
- Citations: 198
- Summary: This paper explores the CRISPR/Cpf1 system, a novel genome-editing tool, and its applications in genetic engineering. It provides an in-depth look at the structure and functions of the Cpf1 protein and its potential advantages over other CRISPR systems like Cas9.
2. Overview of Albumin and Its Purification Methods
- Authors: R. Raoufinia, A. Mota, N. Keyhanvar, F. Safari, S. Shamekhi, J. Abdolalizadeh
- Journal: Advanced Pharmaceutical Bulletin
- Volume: 6
- Issue: 4
- Pages: 495
- Year: 2016
- Citations: 165
- Summary: This review covers the properties of albumin, a critical protein in pharmaceutical and medical applications, and discusses various techniques for its purification, emphasizing its importance in therapeutic use.
3. Immunotoxins in Cancer Therapy: Review and Update
- Authors: B. Akbari, S. Farajnia, S. Ahdi Khosroshahi, F. Safari, M. Yousefi, …
- Journal: International Reviews of Immunology
- Volume: 36
- Issue: 4
- Pages: 207-219
- Year: 2017
- Citations: 149
- Summary: This paper provides an overview of immunotoxins and their evolving role in cancer immunotherapy. It reviews the latest developments in immunotoxin-based treatments, which combine targeted antibody therapy with toxic agents to destroy cancer cells.
4. CRISPR System: A High-Throughput Toolbox for Research and Treatment of Parkinson’s Disease
- Authors: F. Safari, G. Hatam, A.B. Behbahani, V. Rezaei, M. Barekati-Mowahed, …
- Journal: Cellular and Molecular Neurobiology
- Volume: 40
- Pages: 477-493
- Year: 2020
- Citations: 65
- Summary: This article reviews the use of the CRISPR/Cas9 gene-editing system in the context of Parkinson’s disease research and therapy. It highlights high-throughput methods for studying the disease and potential CRISPR-based treatments.
5. CRISPR and Personalized Treg Therapy: New Insights into the Treatment of Rheumatoid Arthritis
- Authors: F. Safari, S. Farajnia, M. Arya, H. Zarredar, A. Nasrolahi
- Journal: Immunopharmacology and Immunotoxicology
- Volume: 40
- Issue: 3
- Pages: 201-211
- Year: 2018
- Citations: 65
- Summary: This review discusses the role of regulatory T cells (Tregs) in the immune system and how CRISPR-based technologies can be used for personalized therapies to treat autoimmune diseases, particularly rheumatoid arthritis.
Conclusion
Dr. Fatemeh Safari is a highly deserving candidate for the Best Researcher Award, given her groundbreaking contributions to medical biotechnology, particularly in genome editing, cell culture, and protein biochemistry. Her research in CRISPR/Cas9 technology, its applications in disease treatment, and her dedication to teaching and mentoring future scientists are noteworthy. While there are opportunities for her to expand the practical applications and international reach of her work, her academic and research achievements already place her at the forefront of her field. The recognition through the Best Researcher Award would not only honor her past achievements but also serve as a platform for the next stage of her career, allowing her to make even greater strides in biotechnology and medical research.