BITS Pilani Hyderabad Campus | India
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Early Academic Pursuits
Dr. Vijaykumar Nimbarte began his academic journey with a Bachelor’s degree in Pharmaceutical Sciences from Nagpur University, India, where he acquired foundational knowledge in pharmaceutics, pharmacology, pharmaceutical chemistry, and pharmacognosy. He further advanced his expertise with an M.S. in Medicinal and Pharmaceutical Chemistry from NIPER Hyderabad, India, focusing on the design, synthesis, and biological evaluation of novel soluble epoxide hydrolase inhibitors with anti-inflammatory potential. During this period, he received the NIPER research assistantship and GPAT fellowship and participated in multiple drug discovery workshops, laying a strong foundation in medicinal chemistry. His Ph.D. at Goethe University, Germany, under the Marie Curie Early Stage Researcher Fellowship, focused on the design, synthesis, and evaluation of novel c-MYC G-Quadruplex stabilizing agents, earning him the highest distinction (magna cum laude).
Professional Endeavors
Following his Ph.D., Dr. Nimbarte expanded his research expertise through several key roles in international academic and industrial settings. He worked as a Project Associate in France at the University of Le Havre, where he developed azaindole-based compounds for anticancer activity. At CSIR-IICT Hyderabad, he contributed to synthesizing PBD-based intercalating agents and novel tubulin polymerase inhibitors. Most recently, he served as a Post-Doctoral Scientist at the Max Planck Institute for Medical Research, Germany, where he focused on structure-based drug design for peripheral neuropathy, collaborating with international research centers to optimize CNS-restricted drug candidates. Since January 2024, he has been an Assistant Professor of Medicinal Chemistry at BITS Pilani, Hyderabad, India.
Contributions and Research Focus
Dr. Nimbarte’s research primarily revolves around medicinal chemistry, structure-based drug design, chemical biology, and the development of biologically active small molecules. His work spans multistep organic synthesis, isotope labeling, and characterization using NMR, Mass, IR, and UV techniques. He has actively contributed to designing compounds that stabilize G-Quadruplex DNA structures, targeting cancer, and developing peripheral-restricted CNS drug candidates, addressing blood-brain barrier permeability issues. He has also applied advanced computational methods, including Schrodinger and ChemAxon software, to improve the efficiency and specificity of drug design.
Impact and Influence
With over 10 years of academic-industrial research experience, Dr. Nimbarte has significantly influenced the field of medicinal chemistry. His projects have successfully transitioned from conceptual design to lead candidate development, demonstrating his ability to combine theoretical design with practical synthesis and biological evaluation. He has collaborated internationally, mentored graduate students, led small group teaching sessions, and contributed to scientific knowledge through presentations and publications.
Academic Citations and Publications
Dr. Nimbarte has published more than 17 research papers in reputable international medicinal chemistry journals, including ChemMedChem. He has served as a potential reviewer for multiple journals such as Medicinal Chemistry Research, Bioorganic and Medicinal Chemistry Letters, Bioorganic Chemistry, and Current Medicinal Chemistry, reflecting his recognition as an expert in his field.
Legacy and Future Contributions
Dr. Nimbarte’s legacy lies in bridging the gap between academic research and practical drug discovery through innovative medicinal chemistry approaches. His work on G-Quadruplex stabilizing agents and peripherally restricted CNS drugs has paved the way for safer, more effective therapeutic candidates. Looking forward, his focus will likely continue on designing targeted small molecules with high therapeutic potential while mentoring the next generation of scientists and expanding interdisciplinary collaborations.
Conclusion
Dr. Vijaykumar Nimbarte exemplifies the integration of deep scientific knowledge, practical drug discovery experience, and academic mentorship. His early academic achievements, international research exposure, and impactful publications reflect a career dedicated to advancing medicinal chemistry. Through his innovative approaches, collaborative ethos, and commitment to teaching, he continues to make significant contributions to both the scientific community and future generations of researchers.
Notable Publications
“Understanding the Impact of Calcineurin Inhibitors on T Cell Regulation: Mechanisms and Clinical Implications"
- Author: VD Nimbarte, SS Sonak, S Ishwarkar
- Journal: Critical Reviews
- Year: 2025
"Modulation of T Cell Regulation by Interleukin-2 Agonists: Mechanisms and Clinical Implications"
- Author: SS Sonak, S Ishwarkar, C Nimbarte, VD Nimbarte
- Journal: Critical Reviews
- Year: 2025
"Synthesis and in Vitro Evaluation of Novel 5‐Nitroindole Derivatives as c‐Myc G‐Quadruplex Binders with Anticancer Activity"
- Author: VD Nimbarte, J Wirmer‐Bartoschek, SL Gande, I Alshamleh, M Seibert
- Journal: ChemMedChem
- Year: 2021
"Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli"
- Author: I Elamri, M Radloff, KF Hohmann, VD Nimbarte, HR Nasiri, M Bolte
- Journal: ChemMedChem
- Year: 2020
"Anti-tyrosinase, anti-cholinesterase and cytotoxic activities of extracts and phytochemicals from the Tunisian Citharexylum spinosum L.: Molecular docking and SAR analysis"
- Author: I Saidi, VD Nimbarte, H Schwalbe, P Waffo-Teguo, AH Harrath, L Mansour
- Journal: Bioorganic Chemistry
- Year: 2020