MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

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MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

Prof Dr. Macaev Fliur Zainutdin  distinguished academic and researcher in the field  Obtaining new compounds with Biological Activity. Born in 1959, Fliur Zainutdin Macaev is a doctor habilitate in organic chemistry, having achieved this title in 2002. He studied chemistry and biology at the Bashkirian State Pedagogical University and earned his PhD from the Institute of Organic Chemistry in Ufa, Bashkortostan, Russia, at the Ural Polytechnic Institute in Sverdlovsk, Russia, under the supervision of Academician Professor Ghenrikh Tolstikov in 1990. Following his doctoral studies, he pursued postdoctoral training in vitamin D3 analogues synthesis at the Institute of Organic Chemistry of the Polish Academy of Sciences (1995-1996) with Professor Jerzy Wicha and in insect-antifeedant synthesis at Wageningen Agricultural University (1998-1999) with Professor Aede de Groot. Since 1999, he has been a prominent member of the Institute of Chemistry of the Academy of Sciences of Moldova, where he serves as the head of the Laboratory of Organic Synthesis.

🌐 Professional Profile

Educations📚📚📚

Fliur Zainutdin Macaev’s educational and career achievements are notable. He was appointed as a Corresponding Member of the Academy of Sciences of Moldova in 2023. He has served as a Professor in Bioorganic Chemistry at the Institute of Chemistry in Chisinau, Moldova, since 2014, and previously held the position of Professor in Organic Chemistry there starting in 2012. He earned his Dr. habilitat in Organic Chemistry from the Institute of Chemistry in Chisinau in 2002 and was promoted to Associate Professor in Organic Chemistry in 1993.Employment  

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Fliur Zainutdin Macaev is a distinguished member of the Moldovan Chemical Society and the Royal Society of Chemistry. His career in research has spanned several decades and institutions. Since 2023, he has been the head of the laboratory at the Institute of Chemistry of Moldova State University. Prior to this, he served as head of the laboratory at the Institute of Chemistry from 2020 to 2022 and at the Institute of Chemistry of the Academy of Sciences of Moldova from 1999 to 2019. His career at the Institute of Chemistry of the Academy of Sciences of Moldova began in 1991, where he held positions ranging from Junior Researcher to Senior Scientific Researcher before becoming a leading scientific researcher in 1995. His specialization includes organic and medicinal chemistry, environmental sciences, nano-chemistry, new catalysts (both metal-mediated and metal-free), asymmetric synthesis, ionic liquids (including magnetic ones), computer-aided molecular design, raw and waste materials chemistry, recycling materials, nano-materials, and bio-films.

current research interest

Specializing in various aspects of organic and medicinal chemistry, he is currently engaged in projects aimed at discovering new catalytic systems, both metal-based and metal-free, for the asymmetric formation of C-C, C-N, and C-P bonds. His work also includes the mechanistic investigation of reactions that proceed with high levels of regio- and stereoselectivity. He is exploring ionic liquids as green alternatives to conventional solvents and is involved in the total synthesis of biologically active compounds and their analogues, employing computer-aided molecular design and structure-activity analysis.

experience

Prof. Macaev has successfully participated in 18 international projects (INTAS projects Ref. № 2000-0711 and Ref. № 2006-8064, MD-US projects CRDF/MC2-3007 and CRDF/MERL-7031, MD-Russia project – Ref. № 06.21CRF, MD-Belarus project Ref. № 05.15BF, MD-Ukraine project Ref. № 10.820.09.01/UA, MD-Germany project Ref. № 09.820.05.08 GF, The Royal Society International Joint Project Ref. № JP090309), STCU Ref. № 5800 as well as member of a group (SCOPES, Ref. Nr.110823), and 8 national projects as coordinator (2000-2005. Ref. № 0101 MD 01915; 2006-2010. Ref. № 06.408.030F.;2011-2012. Ref. № 11.824.08.136T; 2014-2015. Ref. № 14.518.04.08A.; 2011-2014. Ref. № 11.817.08.20F.; 2011-2014. Ref. № 11.817.08.20F.; 2015-2018. Ref. № 15.817.02.17A.; 2015-2018. Ref. № 15.817.02.17A.; 2020-2023. Ref. №20.80009.5007.17).

🏆🏆Awards🏆🏆

Prof. Macaev has received numerous prestigious awards throughout his career. In 1990, he was honored with the prize for young scientific in science and engineering of the USSR, awarded in Kiev, Ukraine. In 2014, he received a Diploma from the Government of the Republic of Moldova for his outstanding results in research. He has been recognized multiple times by the Academy of Sciences of Moldova, receiving awards for scientific achievements in 2019, 2014, 2011, and 2003, as well as a Diploma for high-performance results in 2016 and the Diploma “Academic Merit” in 2014. His accolades also include several gold and silver medals from various international exhibitions. Notably, he won the Gold Medal at the International Exhibition of Scientific Research, Innovation, and Invention Pro Invent 2022 in Cluj-Napoca, Romania, and at the Inventica International Exhibition 2022. He earned Gold and Silver Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2022, 2021, and 2020, and Gold Medals at the “INFOINVENT” International Exhibition in Chisinau, Moldova, in 2019 and 2018. He has also been awarded Gold Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2017 and 2016, and at the International Exhibition “TESLA FEST” in Novi Sad, Serbia, in 2017. Additionally, he received Gold Medals at the International Expo-EUROINVENT in 2012 and 2011, and at the International Expo – Brussels EUREKA INNOVA 2010. He was awarded Bronze Medals at the International Exposition INFOINVENT in Chisinau, Moldova, in 2007 and 2004.

 

📝🔬Publications📝🔬

  1. POGREBNOI, S., RADUL, O., STINGACI, E., LUPASCU, L., VALICA, V., UNCU, L.,SMETANSCAIA, A., PETROU, A., CIRIC, A., GLAMOCLIJA, J., SOKOVIC, M., GERONIKAKI, A. MACAEV, F. Triazolium salts as antifungal agents. Synthesis, biological and in silico evaluation. Anthibiotics 2022,11(5), 588. ISSN 2079-6382. https://doi.org/10.3390/antibiotics11050588
  2. ZVEAGHINTSEVA,, STINGACI, E., POGREBNOI, S., SMETANSCAIA, A., VALICA, V., UNCU, L., KRAVTSOV, V., MELNIC, E., PETROU, A., GLAMOČLIJA, J., SOKOVIĆ, M., CARAZO, A., MLADĚNKA, P., POROIKOV, V., GERONIKAKI, A., MACAEV, F.Z. Chromenols derivatives as novel antifungal agents. Synthesis, In Silico and In Vitro Evaluation biological evaluation and molecular docking. În: Molecules, 2021, 26(14), 4304. (IF: 4.411). ISSN 1420-3049 (Online) DOI: 10.3390/molecules26144304
  3. BILAN, D.Y., SUCMAN, N.S., RADUL, O.M., DRAGALIN, I.P., BARBA, A.N., MACAEV, F. Synthesis of (–)-convolutamydine a derivatives and analogs,  Natur. Comps.  2021, vol. 57, pp. 516-520. DOI: https://doi.org/10.1007/s10600-021-03400-3
  4. CURLAT, S.N., MACAEV, F. Synthesis of 1,2,3-Triazole-Substituted 3,7,7-Trimethylbicyclo[4.1.0]Heptanols Based on (+)-3-Carene. Natur. Comps. 2021, vol. 57, pp. 733-740. https://doi.org/10.1007/s10600-021-03461-4
  5. STINGACI, E.; ZVEAGHINTEVA, M.; POGREBNOI, S.; LUPASCU, L.; VALICA, V.; UNCU, L.; SMETANSCAIA, A.; DRUMEA, M.; PETROU, A.; CIRIC, A.; GLAMOCLIJA, J.; SOKOVIC, M.; KRAVTSOV, V.; GERONIKAKI, A.; MACAEV, F. New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. 2020, 30 (17), 127368. https://doi.org/10.1016/j.bmcl.2020.127368

Patents/Brevets

  1. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor.Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  2. Eremia N., Macaev, F., Pogrebnoi, S., Znagovan, A., Modvala, S., Mardari T., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1598 Z 2022.09.30. BIOPI nr. 4/2022.
  3. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  4. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Pogrebnoi, V., Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1604 B1 acordatdin 03.31. BOPI nr.3/2022
  5. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Zveaghințeva,  Pogrebnoi S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD № 1603 B1 acordat din 2022.03.31. BOPI nr. 3/2022
  6. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E., Zveaghințeva,, Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1591 B1 acordat din 2022.01.31. BOPI nr. 1/2022
  7. Macaev, F.; Stângaci, E.; Pogrebnoi, S.; Boldescu, V. Metodă pentru sinteza 3,3-dialilindolin-2-onei. Institutul de Chimie. Brevet de invenție MD №4739B1, acordat din 01.31.
  8. Macaev,; Stângaci, E.;  Pogrebnoi, S.; Boldescu V. (Z) -5-metil-1- (4-nitrofenil) -2- (1H-1,2,4-triazol-1-il) hex-1-en-3-onă, procedeuşi sinteză ei în calitate de remediu antifungic . Institutul de Chimie. Brevet de invenție MD № 4703C1., eliberat din 2020.07.31.
  9. Macaev, F.; Bilan, D.; Radul, O.; Boldescu, V. Procedeu de sinteza diastereo- și enantioselectivă a (S)-3-hidroxi-3-((R)-2-oxociclohexil) indolin-2-onei. Institutul de Chimie. Brevet de invenție MD № 4689C1., acordat din02.28. BOPI nr.2/2021
  10. Macaev, F.; Zveaghințeva, M.; Stângaci, E.; Pogrebnoi, S.; Lupaşcu, L. Utilizare a (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei în calitate de ingredient activ contra bacteriilor fitopatogene. Institutul de Chimie. Brevet de invenție MD № 4740B1 acordat din02.28. BOPI nr.2/2021

Africa Holguin – human immunodeficiency virus (HIV)- Women Researcher Award

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Africa Holguin – human immunodeficiency virus (HIV)- Women Researcher Award

Dr. Africa Holguin distinguished academic and researcher in the field Human immunodeficiency virus (HIV). She is the Head of the HIV-1 Molecular Epidemiology Laboratory, affiliated with the Microbiology Department at Hospital Ramón y Cajal in Madrid and the Ramón y Cajal Health Research Institute (IRYCIS). As the leader of numerous national and international research projects, she secures funding from both public and private sources, oversees budget administration, and provides the essential expertise and leadership skills to guide and train her team successfully. She has authored over 150 scientific papers in international journals, often serving as the first or last author. Her research group collaborates with national partners and international public health agencies, focusing on well-established pediatric and adult populations across various countries. For more details on her publications, see her Google Scholar profile.

 

🌐 Professional Profile

Educations📚📚📚

She holds a Doctorate in Molecular Biology from Universidad Autónoma de Madrid, Spain, earned in 1996, and a Licentiate in Biological Sciences with a specialization in Biochemistry and Molecular Biology from the same university, completed in 1991. In 2011, she completed the “BIOCAMPUS 2011” Bioentrepreneurship training program, comprising 280 hours, organized by Fundación Genoma España. Additionally, she has undertaken more than 400 hours of training in leadership skills, human resources management, teamwork, coaching, leadership, negotiation, and strategy through various public courses organized by the Instituto de Administración Pública de Madrid (MAP) and the Dirección General de Función Pública de la Comunidad de Madrid.

Research Experiences

She is currently an Investigadora Titular del Sistema Nacional de Salud and the head of the HIV Molecular Epidemiology Laboratory at IRYCIS, Hospital Ramón y Cajal, in Madrid, a position she has held since 2022. Her career includes various roles, starting as a Becaria de Colaboración del MEC at the Centro de Biología Molecular “Severo Ochoa,” CSIC, in Spain from 1989 to 1990. She then served as a predoctoral fellow at the same institution from 1990 to 1996 and a visiting predoctoral researcher at the Dana Farber Cancer Institute, Harvard Medical School, in 1995. From 1996 to 2000, she was a postdoctoral fellow funded by the Fondo de Investigaciones Sanitarias (FIS) at Hospital Carlos III in Madrid. In 1997, she also worked as a visiting postdoctoral researcher at the Georg-Speyer-Haus Institute in Frankfurt, Germany. From 2000 to 2008, she was an investigator at the Sistema Nacional de Salud, Hospital Carlos III. Since 2006, she has been a stabilized investigator at the Fundación para la Investigación Sanitaria del Hospital Ramón y Cajal in Madrid.

Activities of technology / knowledge transfer and results exploitation

  • Actualmente la Unidad de Innovación del Instituto para la Investigación Sanitaria (IRYCIS)
    del Hospital Ramón y Cajal de Madrid está valorando la mejor vía de protección de unos
    aptámeros que reconocen específicamente regiones altamente conservadas de varias
    proteínas del VIH para una futura aplicación diagnóstica.
  • La Dra. Holguín es autora al 40% del programa BioInformático EpiMolBIo (Registro
    2305114294344 en SAFE CREATIVE S.L, 11-5-2023) para analizar secuencias genéticas
    de patógenos y de genes/proteínas de interés biomédico. Con él se analizó la conservación
    de la región de las 5 proteínas del virus usadas para seleccionar los aptámeros anti VIH
    de este proyecto (PMID:35495642, 35694284, 35910645, 33586996), y para estudiar la
    evolución del SARS-CoV-2 en España (PMID:35742840) y mundo (PMID:33557213)
📝🔬Publications📝🔬

1. Scientific paper. Valadés-Alcaraz, A.; Reinosa, R.; González-Hevilla, M.; Medina-Sánchez,
C.; Martín, M. A.; (6/6) Holguín, A. (AC). 2024. Development and characterization of
High-Affinity Aptamers for HIV Protease Detection. (Submitted).Nucleic Acids Research
(Open Acess). (JIF: 14.9, Decil 1 – 10/285, JCR 2022).

2. Scientific paper. Reinosa, R.; Troyano-Hernáez, P.; Valadés-Alcaraz, A.; (4/4) Holguín, A.
(AC). 2024. EpiMolBio: A Novel User-Friendly Bioinformatic Program for Genetic Variability
Analysis. (Submitted).Bioinformatics (Open Access). (JIF: 5.8, Q1 – 24/158 in Bioechnology
& applied Microbiology, JCR 2022).

3. Scientific paper. Rodríguez-Galet, A.; Ventosa-Cubillo, J.; Bendomo, V.; et al; (9/9)
Holguín, A. (AC). 2024. HIV Diagnosis in Equatorial Guinea. Keys to reduce the diagnostic
and therapeutic delay. (Submitted). Journal of Infection and Public Health (Open Acess).
(JIF: 6.7, Q1 – 18/96 in Infectious Diseases, JCR 2022).

4. Scientific paper. Martínez De Aguirre, P.; Carlos, S.; Pina-Sánchez, M.; et al; Reina,
G.; (8/9) Holguín, A.2024. High pre-Delta and early-Omicron SARS-CoV-2 seroprevalence
detected in dried blood samples from Kinshasa (D.R.Congo) (In press).Journal of Medical
Virology (Open Access). (JIF: 12.7, Decil 1 – 2/36, JCR 2022).

5. Scientific paper. Rodríguez-Galet, A.; Ventosa-Cubillo, J.; Eyene, M.; et al; (9/9) Holguín,
A. (AC). 2024. Immunity to six vaccine pathogens in HIV+ and HIV- children in Bata city,
Equatorial Guinea. (In press). Vaccines (Open Acess). (JIF: 7.8, Q1- 24/136 in Medicine,
Research & Experimental, JCR 2022).

6. Scientific paper. Epalza, C.; Valadés-Alcaraz, A.; González-Alba, J.M.; et al; (14/14)
Holguín, A. (AC). 2024. Transmitted Drug Resistance and HIV Diversity Among
Adolescents Newly Diagnosed With HIV in Spain.The Pediatric Infectious Disease Journal
(Open Acess). (JIF: 3.6, Q1 – 23/130 in Pediatrics, JCR 2022).43, pp.40-48. PMID:
37922511. https://doi.org/10.1097/INF.0000000000004138

7. Scientific paper. Mbuagbaw L; Garcia C; Brenner B; et al; Jordan, M.R.; (7/15)
Holguin, A.2023. Checklist for studies of HIV drug resistance prevalence or
incidence: rationale and recommended use.The Lancet HIV (Open Access). (JIF:
16.1, Decil 1 – 6/96 in Infectious Diseases, JCR 2022). 10, pp.e684-e689. PMID:
37716367. https://doi.org/10.1016/S2352-3018(23)00173-X

8. Scientific paper. Ventosa-Cubillo, J.; Pinzón, R.; González-Alba, J.M.; Estripeaut, D.;
Navarro, M.L.; (6/6) Holguín, A. (AC). 2023. Drug resistance in children and adolescents
with HIV in Panama.The Journal of Antimicrobial Chemotherapy (Open Access). (JIF:
5.2, Q1- 55/278 in Pharmacology & Pharmacy