MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

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MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

Prof Dr. Macaev Fliur Zainutdin  distinguished academic and researcher in the field  Obtaining new compounds with Biological Activity. Born in 1959, Fliur Zainutdin Macaev is a doctor habilitate in organic chemistry, having achieved this title in 2002. He studied chemistry and biology at the Bashkirian State Pedagogical University and earned his PhD from the Institute of Organic Chemistry in Ufa, Bashkortostan, Russia, at the Ural Polytechnic Institute in Sverdlovsk, Russia, under the supervision of Academician Professor Ghenrikh Tolstikov in 1990. Following his doctoral studies, he pursued postdoctoral training in vitamin D3 analogues synthesis at the Institute of Organic Chemistry of the Polish Academy of Sciences (1995-1996) with Professor Jerzy Wicha and in insect-antifeedant synthesis at Wageningen Agricultural University (1998-1999) with Professor Aede de Groot. Since 1999, he has been a prominent member of the Institute of Chemistry of the Academy of Sciences of Moldova, where he serves as the head of the Laboratory of Organic Synthesis.

🌐 Professional Profile

Educations📚📚📚

Fliur Zainutdin Macaev’s educational and career achievements are notable. He was appointed as a Corresponding Member of the Academy of Sciences of Moldova in 2023. He has served as a Professor in Bioorganic Chemistry at the Institute of Chemistry in Chisinau, Moldova, since 2014, and previously held the position of Professor in Organic Chemistry there starting in 2012. He earned his Dr. habilitat in Organic Chemistry from the Institute of Chemistry in Chisinau in 2002 and was promoted to Associate Professor in Organic Chemistry in 1993.Employment  

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Fliur Zainutdin Macaev is a distinguished member of the Moldovan Chemical Society and the Royal Society of Chemistry. His career in research has spanned several decades and institutions. Since 2023, he has been the head of the laboratory at the Institute of Chemistry of Moldova State University. Prior to this, he served as head of the laboratory at the Institute of Chemistry from 2020 to 2022 and at the Institute of Chemistry of the Academy of Sciences of Moldova from 1999 to 2019. His career at the Institute of Chemistry of the Academy of Sciences of Moldova began in 1991, where he held positions ranging from Junior Researcher to Senior Scientific Researcher before becoming a leading scientific researcher in 1995. His specialization includes organic and medicinal chemistry, environmental sciences, nano-chemistry, new catalysts (both metal-mediated and metal-free), asymmetric synthesis, ionic liquids (including magnetic ones), computer-aided molecular design, raw and waste materials chemistry, recycling materials, nano-materials, and bio-films.

current research interest

Specializing in various aspects of organic and medicinal chemistry, he is currently engaged in projects aimed at discovering new catalytic systems, both metal-based and metal-free, for the asymmetric formation of C-C, C-N, and C-P bonds. His work also includes the mechanistic investigation of reactions that proceed with high levels of regio- and stereoselectivity. He is exploring ionic liquids as green alternatives to conventional solvents and is involved in the total synthesis of biologically active compounds and their analogues, employing computer-aided molecular design and structure-activity analysis.

experience

Prof. Macaev has successfully participated in 18 international projects (INTAS projects Ref. № 2000-0711 and Ref. № 2006-8064, MD-US projects CRDF/MC2-3007 and CRDF/MERL-7031, MD-Russia project – Ref. № 06.21CRF, MD-Belarus project Ref. № 05.15BF, MD-Ukraine project Ref. № 10.820.09.01/UA, MD-Germany project Ref. № 09.820.05.08 GF, The Royal Society International Joint Project Ref. № JP090309), STCU Ref. № 5800 as well as member of a group (SCOPES, Ref. Nr.110823), and 8 national projects as coordinator (2000-2005. Ref. № 0101 MD 01915; 2006-2010. Ref. № 06.408.030F.;2011-2012. Ref. № 11.824.08.136T; 2014-2015. Ref. № 14.518.04.08A.; 2011-2014. Ref. № 11.817.08.20F.; 2011-2014. Ref. № 11.817.08.20F.; 2015-2018. Ref. № 15.817.02.17A.; 2015-2018. Ref. № 15.817.02.17A.; 2020-2023. Ref. №20.80009.5007.17).

🏆🏆Awards🏆🏆

Prof. Macaev has received numerous prestigious awards throughout his career. In 1990, he was honored with the prize for young scientific in science and engineering of the USSR, awarded in Kiev, Ukraine. In 2014, he received a Diploma from the Government of the Republic of Moldova for his outstanding results in research. He has been recognized multiple times by the Academy of Sciences of Moldova, receiving awards for scientific achievements in 2019, 2014, 2011, and 2003, as well as a Diploma for high-performance results in 2016 and the Diploma “Academic Merit” in 2014. His accolades also include several gold and silver medals from various international exhibitions. Notably, he won the Gold Medal at the International Exhibition of Scientific Research, Innovation, and Invention Pro Invent 2022 in Cluj-Napoca, Romania, and at the Inventica International Exhibition 2022. He earned Gold and Silver Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2022, 2021, and 2020, and Gold Medals at the “INFOINVENT” International Exhibition in Chisinau, Moldova, in 2019 and 2018. He has also been awarded Gold Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2017 and 2016, and at the International Exhibition “TESLA FEST” in Novi Sad, Serbia, in 2017. Additionally, he received Gold Medals at the International Expo-EUROINVENT in 2012 and 2011, and at the International Expo – Brussels EUREKA INNOVA 2010. He was awarded Bronze Medals at the International Exposition INFOINVENT in Chisinau, Moldova, in 2007 and 2004.

 

📝🔬Publications📝🔬

  1. POGREBNOI, S., RADUL, O., STINGACI, E., LUPASCU, L., VALICA, V., UNCU, L.,SMETANSCAIA, A., PETROU, A., CIRIC, A., GLAMOCLIJA, J., SOKOVIC, M., GERONIKAKI, A. MACAEV, F. Triazolium salts as antifungal agents. Synthesis, biological and in silico evaluation. Anthibiotics 2022,11(5), 588. ISSN 2079-6382. https://doi.org/10.3390/antibiotics11050588
  2. ZVEAGHINTSEVA,, STINGACI, E., POGREBNOI, S., SMETANSCAIA, A., VALICA, V., UNCU, L., KRAVTSOV, V., MELNIC, E., PETROU, A., GLAMOČLIJA, J., SOKOVIĆ, M., CARAZO, A., MLADĚNKA, P., POROIKOV, V., GERONIKAKI, A., MACAEV, F.Z. Chromenols derivatives as novel antifungal agents. Synthesis, In Silico and In Vitro Evaluation biological evaluation and molecular docking. În: Molecules, 2021, 26(14), 4304. (IF: 4.411). ISSN 1420-3049 (Online) DOI: 10.3390/molecules26144304
  3. BILAN, D.Y., SUCMAN, N.S., RADUL, O.M., DRAGALIN, I.P., BARBA, A.N., MACAEV, F. Synthesis of (–)-convolutamydine a derivatives and analogs,  Natur. Comps.  2021, vol. 57, pp. 516-520. DOI: https://doi.org/10.1007/s10600-021-03400-3
  4. CURLAT, S.N., MACAEV, F. Synthesis of 1,2,3-Triazole-Substituted 3,7,7-Trimethylbicyclo[4.1.0]Heptanols Based on (+)-3-Carene. Natur. Comps. 2021, vol. 57, pp. 733-740. https://doi.org/10.1007/s10600-021-03461-4
  5. STINGACI, E.; ZVEAGHINTEVA, M.; POGREBNOI, S.; LUPASCU, L.; VALICA, V.; UNCU, L.; SMETANSCAIA, A.; DRUMEA, M.; PETROU, A.; CIRIC, A.; GLAMOCLIJA, J.; SOKOVIC, M.; KRAVTSOV, V.; GERONIKAKI, A.; MACAEV, F. New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. 2020, 30 (17), 127368. https://doi.org/10.1016/j.bmcl.2020.127368

Patents/Brevets

  1. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor.Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  2. Eremia N., Macaev, F., Pogrebnoi, S., Znagovan, A., Modvala, S., Mardari T., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1598 Z 2022.09.30. BIOPI nr. 4/2022.
  3. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  4. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Pogrebnoi, V., Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1604 B1 acordatdin 03.31. BOPI nr.3/2022
  5. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Zveaghințeva,  Pogrebnoi S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD № 1603 B1 acordat din 2022.03.31. BOPI nr. 3/2022
  6. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E., Zveaghințeva,, Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1591 B1 acordat din 2022.01.31. BOPI nr. 1/2022
  7. Macaev, F.; Stângaci, E.; Pogrebnoi, S.; Boldescu, V. Metodă pentru sinteza 3,3-dialilindolin-2-onei. Institutul de Chimie. Brevet de invenție MD №4739B1, acordat din 01.31.
  8. Macaev,; Stângaci, E.;  Pogrebnoi, S.; Boldescu V. (Z) -5-metil-1- (4-nitrofenil) -2- (1H-1,2,4-triazol-1-il) hex-1-en-3-onă, procedeuşi sinteză ei în calitate de remediu antifungic . Institutul de Chimie. Brevet de invenție MD № 4703C1., eliberat din 2020.07.31.
  9. Macaev, F.; Bilan, D.; Radul, O.; Boldescu, V. Procedeu de sinteza diastereo- și enantioselectivă a (S)-3-hidroxi-3-((R)-2-oxociclohexil) indolin-2-onei. Institutul de Chimie. Brevet de invenție MD № 4689C1., acordat din02.28. BOPI nr.2/2021
  10. Macaev, F.; Zveaghințeva, M.; Stângaci, E.; Pogrebnoi, S.; Lupaşcu, L. Utilizare a (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei în calitate de ingredient activ contra bacteriilor fitopatogene. Institutul de Chimie. Brevet de invenție MD № 4740B1 acordat din02.28. BOPI nr.2/2021

P.L. Rodríguez-Kessler – Fisicoquímica computacional – Best Researcher Award

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P.L. Rodríguez-Kessler – Fisicoquímica computacional – Best Researcher Award

Prof Dr. P.L. Rodríguez-Kessler distinguished academic and researcher in the field Fisicoquimica Computacional. 

🌐 Professional Profile

Educations📚📚📚

He earned his Bachelor’s Degree in Physical Engineering from the Autonomous University of San Luis Potosí, UASLP, completing the program from 2002 to 2006. Subsequently, he pursued his Master’s Degree in Materials Science at IPICyT from 2008 to 2010. Continuing his academic journey, he completed his Doctorate in Nanoscience and Materials at the Instituto Potosino de Investigación Científica y Tecnológica IPICyT, located in San Luis Potosí, S. L. P., spanning from 2012 to 2016.

Areas of Interest

 Computational physical chemistry, materials simulation, nanostructures.

Productivity:

48 research articles and appointment as a National Researcher level 1 (SNI) (2024 – 2027). Five years of experience teaching basic sciences courses.

 Research Professor

As a Research Professor, he is currently affiliated with the Centro de Investigaciones en Óptica A. C. since 2022. Additionally, he has taught various courses at the Faculty of Sciences, UASLP. During the autumn semester of 2019, he instructed Differential Calculus for 20 hours per week, Statics and Dynamics for 10 hours per week, and Electricity and Magnetism for 10 hours per week, spanning from August 16, 2019, to February 15, 2020.

  • Introduction to Physics, Physics I, UPSLP Autumn 2011 (August 08 to December 13), 20 hours per week
  • Introduction to Physics, Physics I, UPSLP Spring 2012 (January 23 to June 8), 20 hours per week
  • Physics I, Physics II, UPSLP Autumn 2012 (August 06 to December 12), 20 hours per week
  • Physics I, Physics II, Thermodynamics, UPSLP Autumn 2013 (January 21 to June 7), 30 hours per week
  • Physics, Physics II, UPSLP Autumn 2016 (January 25 to June 8), 20 hours per week
  • Electrical Circuits, UPSLP Autumn 2019 (January 25 to June 8), 20 hours per week
📝🔬Publications📝🔬

Fakher Frikha – Bioinformatics Structural – Top Researcher Award

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 Prof Dr. Fakher Frikha  distinguished academic and researcher in the Bioinformatic stuctural. Fakher’s research fields span Engineering, Computer Science, Biology, Biostatistics, Bioinformatics, and Biochemistry. He has expertise in Biochemistry, Proteins, Lipids, Enzyme Activity, Enzyme Production, Lipase, Laccase, Immobilization, Bioinformatics, Homology Modeling, Molecular Docking, QSAR, Drug Design, Molecular Dynamics Simulation, and Biostatistics. Currently, he works at the Department of Biology, University of Sfax as an assistant professor in bioinformatics and Biostatistics. His current project is mainly in the field of structural bioinformatics and biostatistics, including 3D structures molecular modeling of proteins, molecular dynamics, molecular Docking, study of the structure-function relationship, and design of experiments.

🌐 Professional Profiles

Educations📚📚📚

Fakher Frikha, a Ph.D. holder in Biological Engineering from the National School of Engineers of Sfax (ENIS), has been an Assistant Professor since 2012. His Ph.D. research focused on the molecular modeling of lipolytic enzymes. He also holds a Master’s degree and a National Engineering Degree from ENIS, and a Higher Technician degree in Public Health from the Higher School of Health Sciences and Techniques of Sfax (ESSTSS)

Research projects

Research projects:

  • Dissertation at ESSTSS Microbiology Service, Habib BOURGUIBA University Hospital, Sfax. Topic: “Peripheral samples from newborns: bacteriological analysis and interpretation.”
  • Final project at ENIS Enzymatic Lipolysis Unit, ENIS, Sfax. Topic: “Comparative study of bird lipases.”
  • Master’s thesis at ENIS Laboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, Sfax. Topic: “Modeling 3-D structures of lipases.”
  • Doctoral thesis at ENIS Laboratory of Biochemistry and Enzymatic Engineering of Lipases, ENIS, Sfax. Topic: “Molecular modeling of lipolytic enzymes: study of structure-function relationships.”
  • Member of the Laboratory of Biochemistry and Enzymatic Engineering, ENIS, Sfax (2011).
  • Member of the Laboratory of Microbial, Enzymatic, and Biomolecule Biotechnology (LBMEB), Center of Biotechnology of Sfax (CBS), University of Sfax (2015).
  • Member of the Laboratory of Biochemistry and Enzymatic Engineering, ENIS, Sfax (2018).
  • Member of the Laboratory of Molecular and Cellular Screening Processes (LPCMC), Center of Biotechnology of Sfax (CBS), University of Sfax (August 2021).

Il semble que vous ayez une expérience variée et solide dans le domaine des sciences biologiques et de la recherche, ainsi que dans l’enseignement universitaire. Voici une reformulation de votre expérience professionnelle :

  • Juillet/Août 1999 : Technicien au Laboratoire d’analyse médicale au complexe IBN ANNAFIS, Sfax.
  • 2003 et 2004 : Réussi aux épreuves écrites de recrutement de technologue.
  • Du 15/09/2005 au 15/06/2006, Du 15/09/2006 au 14/09/2007, Du 15/09/2007 au 14/09/2008 : Contrats étudiants chercheurs à l’Institut Supérieur de Biotechnologie de Sfax.
  • À partir du 07/09/2009 : Assistant à la Faculté des Sciences de Sfax, spécialisé en Bioinformatique et Biostatistique (BMC3, SVE3, IAA3, Master BMC) – enseignement de cours théoriques et pratiques. En outre, vous avez assuré des vacations à l’ENIS-GB3 et GB2 en Biotechnologie & Agroalimentaire, ainsi que des travaux pratiques en bioinformatique et en méthodologie de la recherche expérimentale.
  • À partir du 07/09/2012 : Maitre-Assistant à la Faculté des Sciences de Sfax, toujours dans le domaine de la Bioinformatique et Biostatistique (BMC3, SVE3, IAA3, Master Recherche et Master Professionnel) – enseignement de cours théoriques et pratiques.
  • À partir de 2015 : Devenu responsable de la start-up Algreen, dont la mission est de convertir vers un usage parasismique. Cependant, le texte est ambigu, et il n’est pas clair ce que signifie “convert into a para use he”. Si vous pouvez fournir plus de détails sur les activités de la start-up, cela aiderait à clarifier cette partie.

Votre expérience montre une progression professionnelle cohérente dans votre domaine d’expertise, allant de la recherche et de l’enseignement universitaire à des responsabilités entrepreneuriales.

Professional Internships

During his three years of study at the Higher School of Health Sciences and Techniques of Sfax, he completed technician internships in various departments at the Habib BOURGUIBA University Hospital, covering hematology, biochemistry, bacteriology and virology, immunology, and parasitology. From 07/06 to 07/07/2000, he undertook an internship at the pharmaceutical company SIMED in Sfax, focusing on techniques of physico-chemical analysis and microbiological control. From 01/07 to 31/07/2001, he interned at the company AGROMED (Mamie Nova) in El Amra, working on the application of the HACCP system on the production chain of skimmed butter until the finished packaged product.

Additionally, he participated in various educational events and workshops, including the spring pedagogy university event at ENIS in April 2004, the Pedagogical Training Cycle at ENIS in April 2005, and the “First Tunisian-German Workshop on Bioinformatics” in Borj Cédria from 8-10 September 2006, where he presented a poster. He also attended the Training School on Experimental Designs at the University of Sfax from 22-24 March 2007 and participated in the pedagogical training seminar titled “The Place of Self-learning and Information and Communication Technologies” in May 2007, which was organized in collaboration with the Catholic University of Louvain (Belgium) as part of the European TEMPUS program, held at the Higher Institute of Biotechnology of Sfax.

 

📝🔬Publications📝🔬