Sirius university of Science and Technology | Russia
Author Profiles
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Early Academic Pursuits
Dr. Dmitry Guschin began his scientific journey in Moscow, Russia, where his early research as a Research Scientist at the Laboratory of Chromosome Structure (1990–1991) focused on the role of histone tails in maintaining chromatin structure during transcription. This pioneering work, published in Cell, laid the foundation for his long-term interest in chromatin dynamics and molecular mechanisms of gene regulation. His subsequent fellowship at the Imperial Cancer Research Fund in London (1991–1995) enabled him to uncover the role of Jak kinases in interferon signaling, a finding published in Nature. These formative years established his reputation as a molecular biologist with a keen ability to address fundamental questions in gene regulation.
Professional Endeavors
Throughout his career, Dr. Guschin has held prestigious positions across internationally recognized institutions. From visiting scientist roles at Argonne National Laboratory and the NIH, to his decade-long tenure at Sangamo BioSciences (2000–2014), he contributed to groundbreaking advances in genome editing. His later positions at the Institute of Basic Science in Korea (2015–2019), Moscow Institute of Physics and Technology (2019–2022), Ecole Polytechnique (2021), Nazarbaev University (2023–2024), and his current role as Lead Scientist at Sirius University (2024–) reflect a global career marked by innovation, collaboration, and leadership.
Contributions and Research Focus
Dr. Guschin’s research has consistently revolved around genome editing, chromatin biology, and translational medicine. At Sangamo BioSciences, he demonstrated targeted deletions using Zinc-Finger nucleases and developed methods for genome mutation detection, securing 10 U.S. patents. His contributions to CRISPR research at the Institute of Basic Science in Korea, where he engineered Cpf1 (CRISPR type V) proteins with novel PAM specificities, further advanced gene-editing precision. Additionally, his innovations in base editing and co-selection strategies positioned him as a thought leader in functional genomics.
Impact and Influence
The global trajectory of Dr. Guschin’s career underscores his broad scientific influence. His work has impacted both fundamental science-such as uncovering chromatin regulation mechanisms-and applied biotechnology, including methods adopted for therapeutic genome editing. His publications in Cell, Nature, Nature Biotechnology, and Science highlight the international recognition of his discoveries. Moreover, his patents and translational research contributions demonstrate lasting influence on both academia and industry.
Academic Citations
With over 20 peer-reviewed publications in top-tier journals, Dr. Guschin’s scholarship has been widely cited across molecular biology, biochemistry, and genome engineering fields. His publications not only advanced scientific discourse but also served as reference points for subsequent innovations in gene-editing technologies and cancer research.
Legacy and Future Contributions
Dr. Guschin’s legacy lies in bridging basic molecular discoveries with applied genome-editing technologies. His early contributions to chromatin biology and interferon signaling remain benchmarks in molecular biology, while his later work in Zinc-Finger nucleases and CRISPR engineering has influenced therapeutic development pipelines. In his current role at Sirius University, he continues to shape translational medicine by focusing on colloidal medicine and advanced biomedical applications. Looking forward, his expertise positions him to mentor future scientists and contribute to cutting-edge therapies in personalized medicine.
Conclusion
Dr. Dmitry Guschin’s career reflects a rare blend of scientific depth, technological innovation, and translational impact. From uncovering fundamental molecular mechanisms to pioneering genome-editing tools and mentoring the next generation, his contributions have left an indelible mark on modern biology. His ongoing work promises to expand the horizons of translational and personalized medicine, ensuring his influence will continue to grow in both academic and clinical domains.
Notable Publications
"Circulating Tumor DNA in Prostate Cancer: A Dual Perspective on Early Detection and Advanced Disease Management"
- Author: Stepan A. Kopytov; Guzel R. Sagitova; Dmitry Y. Guschin; Vera S. Egorova; Andrei V. Zvyagin; Alexey S. Rzhevskiy
- Journal: Cancers
- Year: 2025
"Modern approaches to engineering human reporter cell lines using CRISPR within Safe Harbor loci and endogenous genes"
- Author: A. G. Bykonya; D. Y. Guschin; N. A. Barlev
- Journal: Critical Reviews in Biotechnology
- Year: 2025
"Vinculin–Arp2/3 interaction inhibits branched actin assembly to control migration and proliferation"
- Author: John James; Artem I Fokin; Dmitry Y Guschin; Hong Wang; Anna Polesskaya; Svetlana N Rubtsova; Christophe Le Clainche; Pascal Silberzan; Alexis M Gautreau; Stéphane Romero
- Journal: Life Science Alliance
- Year: 2025
"BRCA Mutations-The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers"
- Author: Loboda, Anna P.; Adonin, Leonid S.; Zvereva, Svetlana D.; Guschin, Dmitri Y.; Korneenko, Tatyana V.; Telegina, Alexandra V.; Kondratieva, Olga K.; Frolova, Sofia E.; Pestov, Nikolay B.; Barlev, Nick A.
- Journal: International Journal of Molecular Sciences
- Year: 2023
"Vinculin-Arp2/3 Interaction Inhibits Branched Actin Assembly to Control Cell Migration and Cell Cycle Progression"
- Author: John James; Artem I. Fokin; Dmitry Y. Guschin; Hong Wang; Anna Polesskaya; Svetlana N. Rubtsova; Christophe Le Clainche; Pascal Silberzan; Alexis M. Gautreau; Stéphane Romero
- Journal: Preprint
- Year: 2023