MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

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MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

Prof Dr. Macaev Fliur Zainutdin  distinguished academic and researcher in the field  Obtaining new compounds with Biological Activity. Born in 1959, Fliur Zainutdin Macaev is a doctor habilitate in organic chemistry, having achieved this title in 2002. He studied chemistry and biology at the Bashkirian State Pedagogical University and earned his PhD from the Institute of Organic Chemistry in Ufa, Bashkortostan, Russia, at the Ural Polytechnic Institute in Sverdlovsk, Russia, under the supervision of Academician Professor Ghenrikh Tolstikov in 1990. Following his doctoral studies, he pursued postdoctoral training in vitamin D3 analogues synthesis at the Institute of Organic Chemistry of the Polish Academy of Sciences (1995-1996) with Professor Jerzy Wicha and in insect-antifeedant synthesis at Wageningen Agricultural University (1998-1999) with Professor Aede de Groot. Since 1999, he has been a prominent member of the Institute of Chemistry of the Academy of Sciences of Moldova, where he serves as the head of the Laboratory of Organic Synthesis.

🌐 Professional Profile

Educations📚📚📚

Fliur Zainutdin Macaev’s educational and career achievements are notable. He was appointed as a Corresponding Member of the Academy of Sciences of Moldova in 2023. He has served as a Professor in Bioorganic Chemistry at the Institute of Chemistry in Chisinau, Moldova, since 2014, and previously held the position of Professor in Organic Chemistry there starting in 2012. He earned his Dr. habilitat in Organic Chemistry from the Institute of Chemistry in Chisinau in 2002 and was promoted to Associate Professor in Organic Chemistry in 1993.Employment  

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Fliur Zainutdin Macaev is a distinguished member of the Moldovan Chemical Society and the Royal Society of Chemistry. His career in research has spanned several decades and institutions. Since 2023, he has been the head of the laboratory at the Institute of Chemistry of Moldova State University. Prior to this, he served as head of the laboratory at the Institute of Chemistry from 2020 to 2022 and at the Institute of Chemistry of the Academy of Sciences of Moldova from 1999 to 2019. His career at the Institute of Chemistry of the Academy of Sciences of Moldova began in 1991, where he held positions ranging from Junior Researcher to Senior Scientific Researcher before becoming a leading scientific researcher in 1995. His specialization includes organic and medicinal chemistry, environmental sciences, nano-chemistry, new catalysts (both metal-mediated and metal-free), asymmetric synthesis, ionic liquids (including magnetic ones), computer-aided molecular design, raw and waste materials chemistry, recycling materials, nano-materials, and bio-films.

current research interest

Specializing in various aspects of organic and medicinal chemistry, he is currently engaged in projects aimed at discovering new catalytic systems, both metal-based and metal-free, for the asymmetric formation of C-C, C-N, and C-P bonds. His work also includes the mechanistic investigation of reactions that proceed with high levels of regio- and stereoselectivity. He is exploring ionic liquids as green alternatives to conventional solvents and is involved in the total synthesis of biologically active compounds and their analogues, employing computer-aided molecular design and structure-activity analysis.

experience

Prof. Macaev has successfully participated in 18 international projects (INTAS projects Ref. № 2000-0711 and Ref. № 2006-8064, MD-US projects CRDF/MC2-3007 and CRDF/MERL-7031, MD-Russia project – Ref. № 06.21CRF, MD-Belarus project Ref. № 05.15BF, MD-Ukraine project Ref. № 10.820.09.01/UA, MD-Germany project Ref. № 09.820.05.08 GF, The Royal Society International Joint Project Ref. № JP090309), STCU Ref. № 5800 as well as member of a group (SCOPES, Ref. Nr.110823), and 8 national projects as coordinator (2000-2005. Ref. № 0101 MD 01915; 2006-2010. Ref. № 06.408.030F.;2011-2012. Ref. № 11.824.08.136T; 2014-2015. Ref. № 14.518.04.08A.; 2011-2014. Ref. № 11.817.08.20F.; 2011-2014. Ref. № 11.817.08.20F.; 2015-2018. Ref. № 15.817.02.17A.; 2015-2018. Ref. № 15.817.02.17A.; 2020-2023. Ref. №20.80009.5007.17).

🏆🏆Awards🏆🏆

Prof. Macaev has received numerous prestigious awards throughout his career. In 1990, he was honored with the prize for young scientific in science and engineering of the USSR, awarded in Kiev, Ukraine. In 2014, he received a Diploma from the Government of the Republic of Moldova for his outstanding results in research. He has been recognized multiple times by the Academy of Sciences of Moldova, receiving awards for scientific achievements in 2019, 2014, 2011, and 2003, as well as a Diploma for high-performance results in 2016 and the Diploma “Academic Merit” in 2014. His accolades also include several gold and silver medals from various international exhibitions. Notably, he won the Gold Medal at the International Exhibition of Scientific Research, Innovation, and Invention Pro Invent 2022 in Cluj-Napoca, Romania, and at the Inventica International Exhibition 2022. He earned Gold and Silver Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2022, 2021, and 2020, and Gold Medals at the “INFOINVENT” International Exhibition in Chisinau, Moldova, in 2019 and 2018. He has also been awarded Gold Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2017 and 2016, and at the International Exhibition “TESLA FEST” in Novi Sad, Serbia, in 2017. Additionally, he received Gold Medals at the International Expo-EUROINVENT in 2012 and 2011, and at the International Expo – Brussels EUREKA INNOVA 2010. He was awarded Bronze Medals at the International Exposition INFOINVENT in Chisinau, Moldova, in 2007 and 2004.

 

📝🔬Publications📝🔬

  1. POGREBNOI, S., RADUL, O., STINGACI, E., LUPASCU, L., VALICA, V., UNCU, L.,SMETANSCAIA, A., PETROU, A., CIRIC, A., GLAMOCLIJA, J., SOKOVIC, M., GERONIKAKI, A. MACAEV, F. Triazolium salts as antifungal agents. Synthesis, biological and in silico evaluation. Anthibiotics 2022,11(5), 588. ISSN 2079-6382. https://doi.org/10.3390/antibiotics11050588
  2. ZVEAGHINTSEVA,, STINGACI, E., POGREBNOI, S., SMETANSCAIA, A., VALICA, V., UNCU, L., KRAVTSOV, V., MELNIC, E., PETROU, A., GLAMOČLIJA, J., SOKOVIĆ, M., CARAZO, A., MLADĚNKA, P., POROIKOV, V., GERONIKAKI, A., MACAEV, F.Z. Chromenols derivatives as novel antifungal agents. Synthesis, In Silico and In Vitro Evaluation biological evaluation and molecular docking. În: Molecules, 2021, 26(14), 4304. (IF: 4.411). ISSN 1420-3049 (Online) DOI: 10.3390/molecules26144304
  3. BILAN, D.Y., SUCMAN, N.S., RADUL, O.M., DRAGALIN, I.P., BARBA, A.N., MACAEV, F. Synthesis of (–)-convolutamydine a derivatives and analogs,  Natur. Comps.  2021, vol. 57, pp. 516-520. DOI: https://doi.org/10.1007/s10600-021-03400-3
  4. CURLAT, S.N., MACAEV, F. Synthesis of 1,2,3-Triazole-Substituted 3,7,7-Trimethylbicyclo[4.1.0]Heptanols Based on (+)-3-Carene. Natur. Comps. 2021, vol. 57, pp. 733-740. https://doi.org/10.1007/s10600-021-03461-4
  5. STINGACI, E.; ZVEAGHINTEVA, M.; POGREBNOI, S.; LUPASCU, L.; VALICA, V.; UNCU, L.; SMETANSCAIA, A.; DRUMEA, M.; PETROU, A.; CIRIC, A.; GLAMOCLIJA, J.; SOKOVIC, M.; KRAVTSOV, V.; GERONIKAKI, A.; MACAEV, F. New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. 2020, 30 (17), 127368. https://doi.org/10.1016/j.bmcl.2020.127368

Patents/Brevets

  1. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor.Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  2. Eremia N., Macaev, F., Pogrebnoi, S., Znagovan, A., Modvala, S., Mardari T., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1598 Z 2022.09.30. BIOPI nr. 4/2022.
  3. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  4. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Pogrebnoi, V., Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1604 B1 acordatdin 03.31. BOPI nr.3/2022
  5. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Zveaghințeva,  Pogrebnoi S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD № 1603 B1 acordat din 2022.03.31. BOPI nr. 3/2022
  6. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E., Zveaghințeva,, Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1591 B1 acordat din 2022.01.31. BOPI nr. 1/2022
  7. Macaev, F.; Stângaci, E.; Pogrebnoi, S.; Boldescu, V. Metodă pentru sinteza 3,3-dialilindolin-2-onei. Institutul de Chimie. Brevet de invenție MD №4739B1, acordat din 01.31.
  8. Macaev,; Stângaci, E.;  Pogrebnoi, S.; Boldescu V. (Z) -5-metil-1- (4-nitrofenil) -2- (1H-1,2,4-triazol-1-il) hex-1-en-3-onă, procedeuşi sinteză ei în calitate de remediu antifungic . Institutul de Chimie. Brevet de invenție MD № 4703C1., eliberat din 2020.07.31.
  9. Macaev, F.; Bilan, D.; Radul, O.; Boldescu, V. Procedeu de sinteza diastereo- și enantioselectivă a (S)-3-hidroxi-3-((R)-2-oxociclohexil) indolin-2-onei. Institutul de Chimie. Brevet de invenție MD № 4689C1., acordat din02.28. BOPI nr.2/2021
  10. Macaev, F.; Zveaghințeva, M.; Stângaci, E.; Pogrebnoi, S.; Lupaşcu, L. Utilizare a (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei în calitate de ingredient activ contra bacteriilor fitopatogene. Institutul de Chimie. Brevet de invenție MD № 4740B1 acordat din02.28. BOPI nr.2/2021

Laécio Santos Cavalcante – Methods of Synthesis – Best Researcher Award

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Laécio Santos Cavalcante – Methods of Synthesis – Best Researcher Award

Assoc prof Dr. Laecio santos Cavalcante distinguished academic and researcher in the field Method of Synthesis. He holds a degree in Chemistry from the State University of Piauí (UESPI) obtained in 2002.2, completed a Master’s in Physical Chemistry at the Federal University of Piauí (UFPI) in 2005.1, and earned his PhD in Sciences with a concentration in Inorganic Chemistry from the Federal University of São Carlos (UFSCar-SP) in 2009.2. He has completed 3 years of Postdoctoral work at the São Paulo State University of Araraquara (UNESP-SP) in 2012.2 and undertook a 7-month regional and scientific development project (DCR) via the Foundation for Research Support of the State of Piauí (FAPEPI) at UFPI in 2013.1.

Currently, he is a permanent Adjunct Professor of Chemistry (level 03) at UESPI, Poeta Torquato Neto Campus (Teresina), in the Centre for Natural Sciences (CCN) since 2013.2. He is currently researching the following inorganic materials: oxides from the Scheelite/Wolframite families with the general formula [ABO4], tungstates and molybdates with the formulas [A2BO4/A2B3O12], and also some Perovskites with the general formula [ABO3]. His main objective is the structural/electronic analysis and investigation of the photoluminescent and photocatalytic properties of these materials in ordered and/or disordered forms. Additionally, he studies the influence of different compositions of network modifiers (A = Ca, Ba, Sr, Pb, Cd, Ni, Sn, Co, In, Y, Zn, Fe, Bi, Co, Ag, and Mn) and network formers (B = Ti, Zr, W, and Mo) on the electronic structure and physicochemical properties of these ceramic materials. The main synthesis methods he uses are: Polymeric precursors, sonochemical, precipitation, co-precipitation, conventional hydrothermal/solvothermal, and microwave-assisted hydrothermal/solvothermal methods.

🌐 Professional Profile

Educations📚📚📚

He holds a degree in Chemistry from the State University of Piauí (UESPI) obtained in 2002.2, completed a Master’s in Physical Chemistry at the Federal University of Piauí (UFPI) in 2005.1, and earned his PhD in Sciences with a concentration in Inorganic Chemistry from the Federal University of São Carlos (UFSCar-SP) in 2009.2. He has completed 3 years of Postdoctoral work at the São Paulo State University of Araraquara (UNESP-SP) in 2012.2 and undertook a 7-month regional and scientific development project (DCR) via the Foundation for Research Support of the State of Piauí (FAPEPI) at UFPI in 2013.1.

Currently, he is a permanent Adjunct Professor of Chemistry (level 03) at UESPI, Poeta Torquato Neto Campus (Teresina), in the Centre for Natural Sciences (CCN) since 2013.2. He is currently researching the following inorganic materials: oxides from the Scheelite/Wolframite families with the general formula [ABO4], tungstates and molybdates with the formulas [A2BO4/A2B3O12], and also some Perovskites with the general formula [ABO3]. His main objective is the structural/electronic analysis and investigation of the photoluminescent and photocatalytic properties of these materials in ordered and/or disordered forms. Additionally, he studies the influence of different compositions of network modifiers (A = Ca, Ba, Sr, Pb, Cd, Ni, Sn, Co, In, Y, Zn, Fe, Bi, Co, Ag, and Mn) and network formers (B = Ti, Zr, W, and Mo) on the electronic structure and physicochemical properties of these ceramic materials. The main synthesis methods he uses are: Polymeric precursors, sonochemical, precipitation, co-precipitation, conventional hydrothermal/solvothermal, and microwave-assisted hydrothermal/solvothermal methods. (Text provided by the author

📝🔬Publications📝🔬

Rajni Aggarwal -Synthesis of ionic liquids – Women Researcher Award

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Rajni Aggarwal -Synthesis of ionic liquids – Women Researcher Award

Dr. Rajni Aggarwal distinguished academic and researcher in the field Synthesis of ionic liquids. She has accumulated significant teaching experience in the field of chemistry. This includes six months of teaching Organic Chemistry practicals for B.Sc. (HNs) Human Genetics semester I class from July 2011 to November 2012, and another six months teaching the same subject for B.Sc. (HNs) Electronics Technology semester I class from July 2012 to December 2012. Following this, she served for three years as a teacher of Chemistry at BBK DAV College for Women, Amritsar, from 2015 to 2017. Furthermore, she contributed her expertise in the Department of Chemistry from 2022 to 2023, teaching Physical Chemistry to both undergraduate and postgraduate classes over a three-year period

🌐 Professional Profiles

Educations📚📚📚

She holds a B.Sc. in Chemistry (HNs) from Guru Nanak Dev University, Amritsar, obtained in 2007, followed by an M.Sc. in Chemistry (HNs) from the same institution in 2009. During her M.Sc., she conducted a project in inorganic chemistry under the guidance of Dr. T. S. Lobana in the Chemistry Department at GNDU, Amritsar. Subsequently, she pursued her Ph.D. from the Department of Chemistry at Guru Nanak Dev University, Amritsar, under the supervision of Professor Dr. Sukhprit Singh. Her doctoral research focused on the synthesis, characterization, and evaluation of ionic liquids, as well as physical studies related to ionic liquids. Additionally, she has qualified for the Ph.D. Eligibility Test conducted by Guru Nanak Dev University, Amritsar, in August 2010, and the Graduate Aptitude Test conducted by the Indian Institute of Technology (IIT), Bombay, in March 2013.

🏆🏆Awards🏆🏆

 Recipient of UGC SAP Fellowship in science for meritorious student, India (2009 – 2014).

LABORATORY AND INSTRUMENTATION SKILLS

She possesses extensive knowledge and practical skills in various aspects of chemistry, particularly in the realm of organic and inorganic compounds. Her expertise includes conducting multistep organic reactions and monitoring them using techniques such as TLC, UV, fluorescence, NMR, mass spectrometry, and infrared spectroscopy. Additionally, she is proficient in purifying compounds through methods like liquid column chromatography and crystallization.

Furthermore, she is well-versed in the characterization of both organic and inorganic compounds using a wide range of analytical techniques, including NMR, IR, MS, UV-Visible spectroscopy, fluorescence spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and X-ray diffraction (XRD) experiments.

Moreover, she is adept in instrumentation techniques associated with NMR, IR, UV, fluorescence, as well as utilizing software such as Zetasizer for dynamic light scattering (DLS) analysis and XRD analysis. Her proficiency in these areas enables her to contribute effectively to research and teaching endeavors within the field of chemistry.

CONFERENCES ATTENDED

She has actively participated in numerous national symposiums and seminars, showcasing her dedication to advancing knowledge in the field of chemistry. Notable among these are her poster presentations at the National Symposium on Chemistry in 21st Century held at Guru Nanak Dev University, Amritsar, in December 2011, and the Chemical Constellation Cheminar-2012 at Dr B R Ambedkar National Institute of Technology, Jalandhar, in September 2012.

Additionally, she has presented her research findings at various prestigious events, including the 7th RSC-CRSI Symposium in Chemistry at Banaras Hindu University, Varanasi, in January 2013, and the 15th CRSI National Symposium in Chemistry at the same venue in February 2013. Furthermore, she participated in the National Symposium on Recent Trends in Chemistry held at Guru Nanak Dev University, Amritsar, in March 2013.

Her commitment to scholarly discourse is evident through her attendance and contributions at the IVth, Vth, and VIth National Symposia on Advances in Chemical Sciences, all held at Guru Nanak Dev University, Amritsar, in 2014, 2016, and 2017 respectively. These engagements underscore her active involvement in academic and research activities within the chemistry community.

 

📝🔬Publications📝🔬
  • R. Aggarwal, S. Singh, Synthesis, characterization, and evaluation of surface properties of
    cyclohexyloxyoxoethylbipyridinium gemini amphiphiles, and a Comparison with single-tailed
    amphiphiles
  • R. Aggarwal, S. Singh, G. Hundal, Synthesis, characterization and evaluation of surface properties of
    cyclohexanoxycarbonylmethyl pyridinium and cyclohexanoxycarbonyl methyl imidazolium ionic
    liquids.
  • R. Aggarwal, P. Khullar, M. S. Bakshi, D. Mandial, A. Mahal, G. Ahluwalia. Bipyridinium and
    Imidazolium Ionic Liquids for Nanomaterials Synthesis; pH Effect, Phase Transfer Behavior, and
    Protein Extraction. ACS Sustainable Chemistry & Engineering 2017, 5(9), 7859-7870. (DOI:
    10.1021/acssuschemeng.7b01368)
  • R. Aggarwal. Comparison of physicochemical studies of single tailed and gemini cyclohexanoxy
    carbonyl pyridinium cationic amphiphiles. Journal of proteomics and bioinformatics. Volume 10 (7)
    178-185 (2017).
  • R. Aggarwal, S. Singh. Synthesis, characterization and evaluation of surface and thermal properties of
    3-cyclohexyloxy-2-hydroxypropyl pyridinium and imidazolium surface active ionic liquids. Journal of
    surfactant and Detergents, 2018, vol. 21, issue 1, (doi.org/10.1002/jsde.12002).
  • R. Aggarwal, S. Singh. Synthesis, characterization, and evaluation of surface and thermal properties
    and cytotoxicity of 2-hydroxy-3-phenoxypropyl imidazolium bola-type gemini amphiphiles, Journal of
    surfactant and Detergents, 2018, volume 22 (1), (doi/10.1002/jsde.12203)
  • R. Aggarwal, T. S. Lobana, B. Thakur, R. J. Butcher, M. Zeller, J. P. Jasinki. Synthesis and structure of
    dinuclear palladium complexes with 1, 3-imidazoline-2-thione, Acta Cryst. (2023), E79.
  • R. Aggarwal, S. Singh.Synthesis, self-aggregation, thermal stability and cytotoxicity trends of
    alkyloxypropoxycyclohexane based pyridinium ionic liquids.
    https://doi.org/10.1016/j.molliq.2024.124382.