MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

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MACAEV Fliur Zainutdin – Obtaining new compounds with biological Activity – Best Researcher Award

Prof Dr. Macaev Fliur Zainutdin  distinguished academic and researcher in the field  Obtaining new compounds with Biological Activity. Born in 1959, Fliur Zainutdin Macaev is a doctor habilitate in organic chemistry, having achieved this title in 2002. He studied chemistry and biology at the Bashkirian State Pedagogical University and earned his PhD from the Institute of Organic Chemistry in Ufa, Bashkortostan, Russia, at the Ural Polytechnic Institute in Sverdlovsk, Russia, under the supervision of Academician Professor Ghenrikh Tolstikov in 1990. Following his doctoral studies, he pursued postdoctoral training in vitamin D3 analogues synthesis at the Institute of Organic Chemistry of the Polish Academy of Sciences (1995-1996) with Professor Jerzy Wicha and in insect-antifeedant synthesis at Wageningen Agricultural University (1998-1999) with Professor Aede de Groot. Since 1999, he has been a prominent member of the Institute of Chemistry of the Academy of Sciences of Moldova, where he serves as the head of the Laboratory of Organic Synthesis.

🌐 Professional Profile

Educations📚📚📚

Fliur Zainutdin Macaev’s educational and career achievements are notable. He was appointed as a Corresponding Member of the Academy of Sciences of Moldova in 2023. He has served as a Professor in Bioorganic Chemistry at the Institute of Chemistry in Chisinau, Moldova, since 2014, and previously held the position of Professor in Organic Chemistry there starting in 2012. He earned his Dr. habilitat in Organic Chemistry from the Institute of Chemistry in Chisinau in 2002 and was promoted to Associate Professor in Organic Chemistry in 1993.Employment  

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Fliur Zainutdin Macaev is a distinguished member of the Moldovan Chemical Society and the Royal Society of Chemistry. His career in research has spanned several decades and institutions. Since 2023, he has been the head of the laboratory at the Institute of Chemistry of Moldova State University. Prior to this, he served as head of the laboratory at the Institute of Chemistry from 2020 to 2022 and at the Institute of Chemistry of the Academy of Sciences of Moldova from 1999 to 2019. His career at the Institute of Chemistry of the Academy of Sciences of Moldova began in 1991, where he held positions ranging from Junior Researcher to Senior Scientific Researcher before becoming a leading scientific researcher in 1995. His specialization includes organic and medicinal chemistry, environmental sciences, nano-chemistry, new catalysts (both metal-mediated and metal-free), asymmetric synthesis, ionic liquids (including magnetic ones), computer-aided molecular design, raw and waste materials chemistry, recycling materials, nano-materials, and bio-films.

current research interest

Specializing in various aspects of organic and medicinal chemistry, he is currently engaged in projects aimed at discovering new catalytic systems, both metal-based and metal-free, for the asymmetric formation of C-C, C-N, and C-P bonds. His work also includes the mechanistic investigation of reactions that proceed with high levels of regio- and stereoselectivity. He is exploring ionic liquids as green alternatives to conventional solvents and is involved in the total synthesis of biologically active compounds and their analogues, employing computer-aided molecular design and structure-activity analysis.

experience

Prof. Macaev has successfully participated in 18 international projects (INTAS projects Ref. № 2000-0711 and Ref. № 2006-8064, MD-US projects CRDF/MC2-3007 and CRDF/MERL-7031, MD-Russia project – Ref. № 06.21CRF, MD-Belarus project Ref. № 05.15BF, MD-Ukraine project Ref. № 10.820.09.01/UA, MD-Germany project Ref. № 09.820.05.08 GF, The Royal Society International Joint Project Ref. № JP090309), STCU Ref. № 5800 as well as member of a group (SCOPES, Ref. Nr.110823), and 8 national projects as coordinator (2000-2005. Ref. № 0101 MD 01915; 2006-2010. Ref. № 06.408.030F.;2011-2012. Ref. № 11.824.08.136T; 2014-2015. Ref. № 14.518.04.08A.; 2011-2014. Ref. № 11.817.08.20F.; 2011-2014. Ref. № 11.817.08.20F.; 2015-2018. Ref. № 15.817.02.17A.; 2015-2018. Ref. № 15.817.02.17A.; 2020-2023. Ref. №20.80009.5007.17).

🏆🏆Awards🏆🏆

Prof. Macaev has received numerous prestigious awards throughout his career. In 1990, he was honored with the prize for young scientific in science and engineering of the USSR, awarded in Kiev, Ukraine. In 2014, he received a Diploma from the Government of the Republic of Moldova for his outstanding results in research. He has been recognized multiple times by the Academy of Sciences of Moldova, receiving awards for scientific achievements in 2019, 2014, 2011, and 2003, as well as a Diploma for high-performance results in 2016 and the Diploma “Academic Merit” in 2014. His accolades also include several gold and silver medals from various international exhibitions. Notably, he won the Gold Medal at the International Exhibition of Scientific Research, Innovation, and Invention Pro Invent 2022 in Cluj-Napoca, Romania, and at the Inventica International Exhibition 2022. He earned Gold and Silver Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2022, 2021, and 2020, and Gold Medals at the “INFOINVENT” International Exhibition in Chisinau, Moldova, in 2019 and 2018. He has also been awarded Gold Medals at the International Exhibition “Expo-EUROINVENT” in Iasi, Romania, in 2017 and 2016, and at the International Exhibition “TESLA FEST” in Novi Sad, Serbia, in 2017. Additionally, he received Gold Medals at the International Expo-EUROINVENT in 2012 and 2011, and at the International Expo – Brussels EUREKA INNOVA 2010. He was awarded Bronze Medals at the International Exposition INFOINVENT in Chisinau, Moldova, in 2007 and 2004.

 

📝🔬Publications📝🔬

  1. POGREBNOI, S., RADUL, O., STINGACI, E., LUPASCU, L., VALICA, V., UNCU, L.,SMETANSCAIA, A., PETROU, A., CIRIC, A., GLAMOCLIJA, J., SOKOVIC, M., GERONIKAKI, A. MACAEV, F. Triazolium salts as antifungal agents. Synthesis, biological and in silico evaluation. Anthibiotics 2022,11(5), 588. ISSN 2079-6382. https://doi.org/10.3390/antibiotics11050588
  2. ZVEAGHINTSEVA,, STINGACI, E., POGREBNOI, S., SMETANSCAIA, A., VALICA, V., UNCU, L., KRAVTSOV, V., MELNIC, E., PETROU, A., GLAMOČLIJA, J., SOKOVIĆ, M., CARAZO, A., MLADĚNKA, P., POROIKOV, V., GERONIKAKI, A., MACAEV, F.Z. Chromenols derivatives as novel antifungal agents. Synthesis, In Silico and In Vitro Evaluation biological evaluation and molecular docking. În: Molecules, 2021, 26(14), 4304. (IF: 4.411). ISSN 1420-3049 (Online) DOI: 10.3390/molecules26144304
  3. BILAN, D.Y., SUCMAN, N.S., RADUL, O.M., DRAGALIN, I.P., BARBA, A.N., MACAEV, F. Synthesis of (–)-convolutamydine a derivatives and analogs,  Natur. Comps.  2021, vol. 57, pp. 516-520. DOI: https://doi.org/10.1007/s10600-021-03400-3
  4. CURLAT, S.N., MACAEV, F. Synthesis of 1,2,3-Triazole-Substituted 3,7,7-Trimethylbicyclo[4.1.0]Heptanols Based on (+)-3-Carene. Natur. Comps. 2021, vol. 57, pp. 733-740. https://doi.org/10.1007/s10600-021-03461-4
  5. STINGACI, E.; ZVEAGHINTEVA, M.; POGREBNOI, S.; LUPASCU, L.; VALICA, V.; UNCU, L.; SMETANSCAIA, A.; DRUMEA, M.; PETROU, A.; CIRIC, A.; GLAMOCLIJA, J.; SOKOVIC, M.; KRAVTSOV, V.; GERONIKAKI, A.; MACAEV, F. New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters. 2020, 30 (17), 127368. https://doi.org/10.1016/j.bmcl.2020.127368

Patents/Brevets

  1. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor.Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  2. Eremia N., Macaev, F., Pogrebnoi, S., Znagovan, A., Modvala, S., Mardari T., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1598 Z 2022.09.30. BIOPI nr. 4/2022.
  3. Eremia, N., Macaev, F., Krasociko, P., Pogrebnoi, S., Znagovan, A., Neicovcena, I., Coşeleva, O., Eremia, I., Sarî, A. Procedeu de hrănire a albinelor. Brevet de invenție de scurtă durată. Chișinău, MD 1611 Y 2022.04.30. BIOPI nr. 4/2022.
  4. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Pogrebnoi, V., Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1604 B1 acordatdin 03.31. BOPI nr.3/2022
  5. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E.,  Zveaghințeva,  Pogrebnoi S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD № 1603 B1 acordat din 2022.03.31. BOPI nr. 3/2022
  6. Lupașcu, G., Macaev, F., Gavzer, S., Cristea, N., Lupașcu, L., Stângaci,  E., Zveaghințeva,, Pogrebnoi, S. Procedeu de tratare a boabelor de grâu comun de toamnă. Brevet de invenţie de scurtă durată MD №1591 B1 acordat din 2022.01.31. BOPI nr. 1/2022
  7. Macaev, F.; Stângaci, E.; Pogrebnoi, S.; Boldescu, V. Metodă pentru sinteza 3,3-dialilindolin-2-onei. Institutul de Chimie. Brevet de invenție MD №4739B1, acordat din 01.31.
  8. Macaev,; Stângaci, E.;  Pogrebnoi, S.; Boldescu V. (Z) -5-metil-1- (4-nitrofenil) -2- (1H-1,2,4-triazol-1-il) hex-1-en-3-onă, procedeuşi sinteză ei în calitate de remediu antifungic . Institutul de Chimie. Brevet de invenție MD № 4703C1., eliberat din 2020.07.31.
  9. Macaev, F.; Bilan, D.; Radul, O.; Boldescu, V. Procedeu de sinteza diastereo- și enantioselectivă a (S)-3-hidroxi-3-((R)-2-oxociclohexil) indolin-2-onei. Institutul de Chimie. Brevet de invenție MD № 4689C1., acordat din02.28. BOPI nr.2/2021
  10. Macaev, F.; Zveaghințeva, M.; Stângaci, E.; Pogrebnoi, S.; Lupaşcu, L. Utilizare a (Z)-4,4-dimetil-1-(4-nitrofenil)-2-(1H-1,2,4-triazol-1-il)pent-1-en-3-onei în calitate de ingredient activ contra bacteriilor fitopatogene. Institutul de Chimie. Brevet de invenție MD № 4740B1 acordat din02.28. BOPI nr.2/2021

Canan Uluoglu – Pharmacology – Best Researcher Award

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Canan Uluoglu – Pharmacology – Best Researcher Award

Dr. Canan Uluoglu distinguished academic and researcher in the field Pharmacology. She was awarded a postdoctoral scholarship at Ferrara University, where she worked in the Department of Clinical and Experimental Medicine’s Molecular and Cellular Pharmacology Unit from 2000 to 2001.

Her committee memberships include serving as a member of the Turkish Health Ministry’s Drug Regulatory Commission from 2015 to 2017, being a part of the Gazi University Clinical Research Ethics Committee from 2003 to 2018, and participating in the Turkish Scientific and Technological Research Council (TUBITAK) from 2010 to 2014.

Her research interests encompass Basic and Clinical Pharmacology, Chronopharmacology, and Neuropharmacology.

 

🌐 Professional Profile

Educations📚📚📚

She completed her medical education at Gazi University School of Medicine in Ankara, Turkey, graduating in 1989. In 1998, she became a Research Assistant and earned her PhD from the Department of Pharmacology at the same institution. Her academic career progressed as she was appointed as an Associate Professor in the Department of Pharmacology in 2003. By 2009, she had achieved the rank of Professor in the same department, continuing her contributions to the field of pharmacology at Gazi University School of Medicine.

📝🔬Publications📝🔬
  • ZS Ercan, RK Türker, C Uluoğlu, Ö Yazar, H Zengil. “The effects of endothelin peptides in the rabbit isolated perfused kidney.” General Pharmacology. 25(7):1471-1476 (1994). ISSN: 0306-3623
  • U Hodoğlugil, C Uluoğlu, HZ Güney, CZ Görgün, ZS Ercan, N Abacıoğlu, H Zengil. “Twenty-four-hour variations in the effect of nitrodilators in rat aorta: lack of influence of the endothelium”. Journal of Pharmacy and Pharmacology. 49(11):1102-1108 (1997). ISSN:2042-7158
  • HZ Güney, U Hodoğlugil, C Uluoğlu, CZ Görgün, ZS Ercan, N Abacıoğlu, H Zengil. In vitro susceptibility rhythms. II. Biological-time-dependent differences in effect of b1 -and b2 – adrenergic agonists of rat aorta and influence of endothelium. Chronobiology International. 15(2): 159-172 (1998). Print ISSN: 0742-0528 Online ISSN: 1525-6073
  • C Uluoğlu, HZ Güney, M Kılınç, Ş Bozkurt, ZS Ercan. “The effects of captopril and naloxone on restraint-cold-stress- and ethanol-induced gastric lesions in rats.” General Pharmacology. 30(5):701-704 (1998). ISSN: 0306-3623
  • C Uluoğlu, U Hodoğlugil, HZ Güney, CZ Görgün, N Abacıoğlu, H Zengil. “Daily variations in the responses to papaverine but not theophylline in rat aorta.” Biological Rhythm Research. 29(4): 343-352 (1998). ISSN: 0929-1016 Online ISSN: 1744-4179
  • C Uluoğlu, A Oğuz, Ö Timlioğlu, G Biberoğlu, A Hasanoğlu. “Intermediate dose of methotrexate toxicity in non-Hodgkin lymphoma.” General Pharmacology. 32(2): 215-218 (1999). ISSN: 0306-3623
  • U Hodoğlugil, ZA Keskil, CZ Görgün, C Uluoğlu, N Abacıoğlu, H Zengil. “Effect of time on endothelium-dependent relaxations in mice and rat thoracic aortas.” Biological Rhythm Research. 30(4): 434-444 (1999). Print ISSN: 0929-1016 Online ISSN: 1744-4179
  • O Uludağ, B Tunçtan, HZ Güney, C Uluoğlu, S Altuğ, H Zengil, N Abacıoğlu. “Temporal variation in serum nitrite levels in rats and mice.” Chronobiology International.  16(4): 527-532 (1999). ISSN: 1525-6073
  • HZ Güney, C Uluoğlu, U Hodoğlugil, CZ Görgün, T Yamanoğlu, N Abacıoğlu, H Zengil. “Biological-time-dependent differences in effect of verapamil in rat aorta and influence of endothelium.” Chronobiology International.  16(6): 779-787 (1999). ISSN: 1525-6073
  • C Uluoğlu, Timlioğlu Ö. “Endothelium-dependent vasodilation in the isolated rabbit kidney following in vivo and in vitro ischaemia-reperfusion: effects of antagonizing platelet activating factor (PAF). “Naunyn-Schmiedeberg’s Archives of Pharmacology. 360(3): 324-330 (1999).

Xianfu Wu – Pharmaceutical Analysis Award – Best Researcher Award

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Xianfu Wu – Pharmaceutical Analysis Award – Best Researcher Award

Prof Dr. Xianfu Wu distinguished academic and researcher in the field Pharmaceutical Analysis.  Xianfu Wu was graduated with his Ph.D degree of medicinal chemistry from Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC) in 2009. Then he joined the faculty at Institute of Microbiology, Chinese Academy of Sciences as associate professor. In 2012, He moved to National Institutes for Food and Drug Control of National Medical Products Administration (NMPA). Dr. Wu’s research interest is mainly focused on the studying on drug quality control and drug reference standards

🌐 Professional Profiles

Educations📚📚📚

He pursued his academic journey with a keen focus on medicinal chemistry, culminating in a Ph.D. from the Institute of Materia Medica at the Chinese Academy of Medical Sciences & Peking Union Medical College in 2009. Prior to his doctoral studies, he completed a Master’s degree in Medicinal Chemistry at Shenyang Pharmaceutical University in 2006, building upon his foundational education in the Science of Chinese Materia Medica, which he obtained from Hubei University of Chinese Medicine in 2003. Throughout his educational endeavors, he demonstrated a deep-seated commitment to advancing his expertise in the field of medicinal chemistry, laying a solid groundwork for his future endeavors in pharmaceutical research and development.

 Work experiences

He assumed various roles within the academic and research spheres, showcasing his expertise and leadership capabilities. Since June 2012, he has served as a Professor, Master’s Supervisor, and Director of the Department at the National Institutes for Food and Drug Control under the National Medical Products Administration (NMPA) in China. In this capacity, he has been instrumental in guiding research initiatives and overseeing the regulatory aspects of food and drug control in the country. Prior to this, from August 2009 to June 2012, he held the position of Research Associate at the Institute of Microbiology within the Chinese Academy of Sciences, contributing to advancements in microbiological research and fostering collaborations within the scientific community. Throughout his career, he has consistently demonstrated a dedication to excellence and a passion for furthering scientific knowledge and regulatory standards in his field.

Research Directions

He has been actively engaged in diverse research areas, showcasing his versatility and breadth of expertise. His investigations encompass a wide array of topics, including the exploration of new technologies and methodologies for enhancing drug quality control, reflecting his commitment to staying at the forefront of scientific advancements. Furthermore, his research delves into the application of nuclear magnetic resonance spectroscopy within complex drug systems, highlighting his proficiency in utilizing advanced analytical techniques to elucidate molecular structures and dynamics. Additionally, he has contributed significantly to the field of drug quality control through his studies, demonstrating a meticulous approach to ensuring the safety and efficacy of pharmaceutical products. Moreover, his investigations into the bioactive substances and functional properties of natural medicines underscore his interest in harnessing the therapeutic potential of natural compounds for medicinal purposes. Through his multifaceted research endeavors, he continues to make significant strides in advancing our understanding of pharmaceutical science and its applications in healthcare.

Grants & Research Projects

He has secured several prestigious grants and research projects, showcasing his leadership in securing funding and his dedication to advancing scientific knowledge. Among these projects is the National Natural Science Foundation of China-funded research on the “Antitumor activity of benzophenone derived from endophytic fungi of the genus Pestalotiopsis” (Project No.: 81102338), highlighting his focus on exploring natural compounds for potential therapeutic applications. Additionally, he has led initiatives supported by the Technology Foundation of the General Administration of Quality Supervision, Inspection, and Quarantine of China, such as the project addressing the urgent need for “Chemical reference materials in safety testing of cosmetics in China” (Project No.: 2012104008), demonstrating his commitment to regulatory standards and consumer safety. Moreover, his involvement in projects aimed at improving the standards of the Chinese Pharmacopoeia Committee, including the identification of low molecular weight heparin series products by nuclear magnetic resonance spectrum (Project No.: 443) and the study on the determination technique of water-solid interaction in drug systems (Project No.: 2019Y16), underscores his expertise in pharmaceutical quality control and analytical techniques. Through his leadership and involvement in these projects, he continues to make significant contributions to the advancement of pharmaceutical science and regulatory standards in China.

Achievements

His achievements exemplify a distinguished career marked by significant contributions to pharmaceutical science and regulatory standards. Notably, he played a pivotal role in drafting Chinese Pharmacopoeia standards for nuclear magnetic resonance identification of three low molecular weight heparin products, namely dalteparin sodium, nadroparin calcium, and enoxaparin sodium, enhancing the quality control of these crucial pharmaceuticals. Furthermore, his research on the dynamic vapor adsorption method in pharmaceuticals and reference standards has laid a solid groundwork for its application and dissemination within the industry. His systematic exploration of nuclear magnetic resonance spectroscopy has yielded innovative methods for quantifying drug content, detecting impurities, and controlling residual solvents, thereby revolutionizing drug quality assessment. Additionally, his extensive work in natural product isolation has led to the discovery of over 90 compounds, including more than 30 novel ones, expanding the structural diversity of natural product compounds. Moreover, his leadership in developing over 130 new drug reference standards has provided indispensable support for the advancement of the drug industry and regulatory oversight, further solidifying his reputation as a trailblazer in pharmaceutical research and development.

📝🔬Publications📝🔬