Education Background 🎓📖
- Ph.D. in Microbiology, specializing in bacterial signaling and host-pathogen interactions.
- Advanced training in microbial biotechnology and infection biology.
- Extensive academic and research experience in bacterial second messengers, drug target discovery, and immune responses.
Professional Development 📈💡
As a leading researcher in microbiology, Dr. Li has made significant contributions to the study of bacterial cyclic di-GMP signaling, microbial drug targets, and host immunity mechanisms. He has supervised multiple Ph.D. students and led major research projects in microbiology and biotechnology.
Research Focus 🔬📖
- Discovery of receptors and functions of the second messenger cyclic di-GMP in bacteria
- Microbial drug targets and antibiotic resistance
- Microbial infection and host immune response
Author Metrics
Dr. Li has published extensively in high-impact microbiology and biotechnology journals, contributing to advancements in bacterial signaling and infection biology. His work is widely cited, reflecting his influence in the field.
Awards & Honors 🏆🎖️
Dr. Li has received multiple awards and recognitions for his contributions to microbiology, particularly in the fields of bacterial signaling and antimicrobial resistance. His work has significantly influenced the understanding of Mycobacteria and bacterial adaptation mechanisms.
Publication Top Notes
1. NapR Regulates the Expression of Phosphoserine Aminotransferase SerC to Modulate Biofilm Formation and Resistance to Serine Stress of Mycobacteria
📅 Published: February 28, 2025
📑 Journal: International Journal of Molecular Sciences
🔗 DOI: 10.3390/ijms26052181
📖 ISSN: 1422-0067
👥 Authors: Minhao Guo, Xiaocui Ling, Linzhao He, Yukuo Gou, Zhun Li, Weihui Li
📌 Summary: This study explores how NapR regulates SerC, influencing biofilm formation and serine stress resistance in Mycobacteria, with potential implications for bacterial survival and antibiotic resistance.
2. Cu²⁺ Mediates the Oxidation of the Transcription Factor MscA to Regulate the Antioxidant Defense of Mycobacteria
📅 Published: January 7, 2025
📑 Journal: Nucleic Acids Research
🔗 DOI: 10.1093/nar/gkae1309
📖 ISSN: 0305-1048 / 1362-4962
👥 Authors: Yuling Xiang, Jiachen Zheng, Zhendong Liu, Xujie Cui, Yunfan Zhang, Minhao Guo, Weihui Li
📌 Summary: This paper investigates how Cu²⁺ regulates MscA, a transcription factor crucial for the antioxidant defense system in Mycobacteria, shedding light on oxidative stress response mechanisms.
3. Lsr2 Acts as a Cyclic di-GMP Receptor that Promotes Keto-Mycolic Acid Synthesis and Biofilm Formation in Mycobacteria
📅 Published: January 24, 2024
📑 Journal: Nature Communications
🔗 DOI: 10.1038/s41467-024-44774-6
📖 ISSN: 2041-1723
👥 Authors: Xiaocui Ling, Xiao Liu, Kun Wang, Minhao Guo, Yanzhe Ou, Danting Li, Yulin Xiang, Jiachen Zheng, Lihua Hu, Hongyun Zhang, Weihui Li
📌 Summary: This research identifies Lsr2 as a cyclic di-GMP receptor in Mycobacteria, linking it to mycolic acid synthesis and biofilm formation, which are crucial for bacterial virulence and drug resistance.
4. Responsive Metal–Organic Framework Nanocarrier Delivery System: An Effective Solution Against Bacterial Infection
📅 Published: December 2023
📑 Journal: Coordination Chemistry Reviews
🔗 DOI: 10.1016/j.ccr.2023.215431
📖 ISSN: 0010-8545
👥 Authors: Yi Liu, Jinmei Wu, Weihui Li, Jinquan Li, Heyou Han, Zhiyong Song
📌 Summary: This study presents a metal–organic framework (MOF) nanocarrier system that targets bacterial infections, offering a novel drug delivery approach for antimicrobial therapy.
5. PatA Regulates Isoniazid Resistance by Mediating Mycolic Acid Synthesis and Controls Biofilm Formation by Affecting Lipid Synthesis in Mycobacteria
📅 Published: June 15, 2023
📑 Journal: Microbiology Spectrum
🔗 DOI: 10.1128/spectrum.00928-23
📖 ISSN: 2165-0497
👥 Authors: Kun Wang, Yimin Deng, Xujie Cui, Mengli Chen, Yanzhe Ou, Danting Li, Minhao Guo, Weihui Li
📌 Summary: This paper explores the role of PatA in isoniazid resistance in Mycobacteria, revealing its influence on mycolic acid and lipid synthesis, which are critical for drug resistance and biofilm development.
Conclusion:
Prof. Weihui Li is a highly deserving candidate for the Best Researcher Award in microbiology and biotechnology. His groundbreaking research on bacterial signaling, biofilm formation, and antimicrobial resistance has significantly impacted the field. His scientific output, leadership, and contributions to fundamental and applied microbiology make him a strong competitor.
By fostering interdisciplinary collaborations and enhancing public engagement, Prof. Li can further solidify his position as a global leader in microbiology research. Given his exceptional academic record and influential publications, he is an ideal nominee for this prestigious award.