1. In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles
Authors: Y. Zhang, A. Satterlee, L. Huang
Journal: Molecular Therapy, 2012, 20(7), pp. 1298–1304
Citations: 470
Summary:
This paper discusses the challenges of in vivo gene delivery using nonviral vectors, emphasizing strategies to overcome barriers such as stability, targeting efficiency, and cellular uptake. The study highlights advancements in nanotechnology and biomaterials that enhance the potential of nonviral vectors for clinical applications in gene therapy.
2. Delivering Safer Immunotherapies for Cancer
Authors: L. Milling, Y. Zhang, D.J. Irvine
Journal: Advanced Drug Delivery Reviews, 2017, 114, pp. 79–101
Citations: 305
Summary:
The paper reviews recent developments in cancer immunotherapies, focusing on minimizing systemic toxicity while enhancing efficacy. It explores strategies such as targeted delivery systems, immune checkpoint inhibitors, and nanocarriers to ensure safer and more effective immunotherapy solutions.
3. Nanoparticle Anchoring Targets Immune Agonists to Tumors Enabling Anti-Cancer Immunity Without Systemic Toxicity
Authors: Y. Zhang, N. Li, H. Suh, D.J. Irvine
Journal: Nature Communications, 2018, 9(1), Article 6
Citations: 215
Summary:
This study introduces a novel nanoparticle system for targeting immune agonists directly to tumors, thereby inducing a potent anti-cancer immune response. The method reduces systemic toxicity and enhances the therapeutic index of immune-based treatments, representing a breakthrough in cancer immunotherapy.
4. Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐Ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy
Authors: D. Shao, F. Zhang, F. Chen, X. Zheng, H. Hu, C. Yang, Z. Tu, Z. Wang, Y. Zhang, et al.
Journal: Advanced Materials, 2020, 32(50), Article 2004385
Citations: 199
Summary:
The paper presents innovative mesoporous organosilica nanoparticles with diselenide bridges for X-ray-triggered chemo-immunotherapy. These nanoparticles are biodegradable, providing a controlled drug release system that combines chemotherapy and immunotherapy for enhanced anti-cancer efficacy.
5. Lipid-Coated Cisplatin Nanoparticles Induce Neighboring Effect and Exhibit Enhanced Anticancer Efficacy
Authors: S. Guo, Y. Wang, L. Miao, Z. Xu, C.M. Lin, Y. Zhang, L. Huang
Journal: ACS Nano, 2013, 7(11), pp. 9896–9904
Citations: 145
Summary:
This research develops lipid-coated cisplatin nanoparticles that induce a “neighboring effect,” enhancing anticancer efficacy. The study demonstrates the nanoparticles’ ability to selectively target cancer cells, improve drug delivery, and minimize off-target toxicity, making them a promising candidate for advanced chemotherapy.